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In machine learning, generative adversarial networks (GANs) involve two artificial neural networks squaring off, one, the generator, trying to delude the other, the discriminator, into accepting synthetic data as real. Beyond their science and engineering applications, GANs can generate utterly convincing "photographs" of people who do not exist.

Unrestricted use on a wide scale of electronic health records (EHRs) for biomedical or health services research is precluded by patient privacy considerations. Simulated EHRs could help speed discovery.

In a study in the Journal of the American Medical Informatics Association, Chao Yan, Ziqi Zhang, Bradley Malin, and colleagues use GANs to generate "electronic records" of patients who do not exist.

Using some 1 million de-identified EHRs as a training set, the team refined the training, design and statistical evaluation of GANs for EHR simulation. Evaluated against earlier learning models, their medical GAN more closely mimics real-world data while providing training-set patients a similar level of protection from prospective privacy attacks.

More information: Ziqi Zhang et al. Ensuring electronic medical record simulation through better training, modeling, and evaluation, Journal of the American Medical Informatics Association (2019). DOI: 10.1093/jamia/ocz161

Journal information: Journal of the American Medical Informatics Association