Incidence of early-onset gastric cancer increasing in the U.S.

Incidence of early-onset gastric cancer increasing in the U.S.

(HealthDay)—The incidence of early-onset gastric cancer has been increasing in the United States, and it seems to be distinct clinically and genetically from late-onset gastric cancer, according to a study recently published in Surgery.

John R. Bergquist, M.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues examined clinical and genomic characteristics and risk factors for early-onset versus late-onset using data from the Surveillance, Epidemiology, and End Results database (1973 to 2015), the Behavioral Risk Factor Surveillance Survey, and The Cancer Genome Atlas.

The researchers found that during the study period, the incidence of early-onset gastric cancer increased, now comprising more than 30 percent of all gastric cancer in the United States. Compared with late-onset disease, early-onset gastric cancer was associated with higher grade (55.2 versus 46.9 percent), signet-ring cells (19.0 versus 10.4 percent), diffuse histology (25.7 versus 15.0 percent), and metastatic disease (49.5 versus 40.9 percent). Late-onset gastric cancer was more likely to be microsatellite instability subtype (18.6 versus 5.6 percent), whereas early-onset disease was more likely to be Epstein Barr virus (7.7 versus 5.1 percent) or genomically stable (22.5 versus 8.1 percent) subtype. Compared with late-onset gastric cancer, for gastric cancer were less correlated with early-onset disease.

"Typically, we see stomach cancer being diagnosed in patients in their 70s, but increasingly we are seeing 30- to 50-year-old patients being diagnosed," a coauthor said in a statement. "Hopefully, studies like this will raise awareness and increase physician suspicion of , particularly in younger patients."


Explore further

Many younger patients with stomach cancer have a distinct disease, research discovers

More information: Abstract/Full Text (subscription or payment may be required)
Journal information: Surgery

Copyright © 2019 HealthDay. All rights reserved.

Citation: Incidence of early-onset gastric cancer increasing in the U.S. (2020, January 2) retrieved 29 October 2020 from https://medicalxpress.com/news/2020-01-incidence-early-onset-gastric-cancer.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
9 shares

Feedback to editors

User comments