Adding maraviroc to standard c-ART does not seem to improve clinical outcomes for patients with advanced HIV infection

Adding maraviroc to standard combined antiretroviral therapy (c-ART) does not seem to improve clinical outcomes for patients initiating treatment for advanced HIV infection. Findings from a double-blind randomized controlled trial are published in Annals of Internal Medicine.

One-third of with HIV in resource-rich countries are diagnosed late in the disease. These patients with advanced HIV infection face increased risk for AIDs-defining events and mortality due to , which may be related to weakened immunity. Maraviroc, an antiretroviral drug with immunologic effects, could benefit such patients.

Researchers from Henri Mondor Hospital, Créteil, France, randomly assigned 416 HIV-positive adults initiating treatment with c-ART for the first time to either C-ART plus placebo or maraviroc for 72 weeks to assess the benefit of adding maraviroc to standard c-ART. The researchers found that among persons diagnosed with advanced HIV infection in 3 European countries, the incidence of severe morbidity was 11.2 per 100 person-years, and adding maraviroc to standard c-ART for these patients had no effect on this. Maraviroc use was associated with higher risk for virologic failure at week 48 but not at week 72. The gain in CD4 T-cell count was similar in both groups throughout the study but increase in CD4-CD8 ratio was lower in the maraviroc group.

The authors conclude that maraviroc seems to show no clinical benefit for patients diagnosed with advanced HIV.


Explore further

Maraviroc-containing regimens safe, tolerable when taken for HIV prevention

More information: Annals of Internal Medicine (2020). http://annals.org/aim/article/doi/10.7326/M19-2133
Journal information: Annals of Internal Medicine

Citation: Adding maraviroc to standard c-ART does not seem to improve clinical outcomes for patients with advanced HIV infection (2020, February 11) retrieved 25 November 2020 from https://medicalxpress.com/news/2020-02-adding-maraviroc-standard-c-art-clinical.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
2 shares

Feedback to editors

User comments