Model shows hep C-infected kidney transplants beneficial, cost-effective

Model shows hep C-infected kidney transplants beneficial, cost-effective

(HealthDay)—Transplanting hepatitis C virus (HCV)-infected kidneys into uninfected recipients and then treating patients with antiviral therapy leads to a higher quality of life and is less costly than waiting for transplantation with an uninfected kidney, according to a study recently published in the American Journal of Kidney Diseases.

Mark H. Eckman, M.D., from the University of Cincinnati Medical Center, and colleagues used a Markov state transition decision model to examine the effectiveness of (in quality-adjusted life years) and costs associated with transplantation with an HCV-unexposed kidney versus an HCV-infected kidney with HCV antiviral treatment. Participants included dialysis patients on waiting lists.

The researchers found that transplanting HCV-infected kidneys into uninfected recipients increased survival by 1.19 quality-adjusted life years and reduced lifetime costs by $37,918 compared with transplanting kidneys from HCV-unexposed donors. The investigators note that the benefits stem from the excess mortality risk for , the high efficacy of antiviral HCV treatments, and the substantially shorter wait times for HCV-infected kidneys. The average wait time for an HCV-infected kidney was 1.56 years, and this transplantation approach was cost-effective as long as the wait-time for an infected kidney did not exceed 3.1 years.

"This matters because patients on dialysis have a much higher risk of dying each year," Eckman said in a statement. "Anything that can shorten the number of years the patient is on dialysis waiting for a transplant is an improvement. That's the benefit of accepting an HCV-infected ."

Several authors disclosed financial ties to pharmaceutical companies.

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Citation: Model shows hep C-infected kidney transplants beneficial, cost-effective (2020, April 6) retrieved 30 November 2023 from
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