Superbug impact on the gut

Superbug impact on the gut
E Cadherin and Beta Catenin stained infected mouse colonic tissue. Credit: (c) Monash BDI

Monash University researchers have discovered that the devastating bacterial superbug Clostridioides difficile hijacks the human wound healing system in order to cause serious and persistent disease, opening up the development of new therapies to treat the disease.

Clostridioides difficile is the most common hospital-acquired disease and causes persistent and life-threatening —particularly in elderly and immunocompromised patients.

The infection is very difficult to treat, and often repeatedly reoccurs in patients even after they have been given powerful and debilitating antibiotics for many months. C. difficile is also highly resistant to antibiotics, which greatly complicates treatment.

A team based in the Monash Biomedicine Discovery Institute (BDI) found that C. difficile massively activates a human enzyme called plasminogen in order to destroy gut tissue and to help spread the infection throughout the patient. Ordinarily, plasminogen, and its active form plasmin, is deployed in a highly controlled fashion to break down scar tissue and help wounds heal.

"The results were a huge surprise, and revealed that the severe damage caused to the gut by C. difficile was actually caused by a human enzyme rather than a bacterial toxin," said study co-leader and infectious disease expert Prof Dena Lyras.

Given their findings, the researchers decided to investigate whether developed by the team and that inhibited the plasminogen / plasmin system could be used to treat the disease.

"We found that an antibody that prevented plasminogen from being activated dramatically stalled the progress of infection and ," said first author Milena Awad.

The researchers now aim to commercialize their antibodies in order to treat a range of bacterial and .

An advantage of targeting a human protein in an infectious disease is that resistance to the therapy is far less likely to occur.

"The antibody could have broad utility, since the plasminogen / plasmin system is dysregulated in a range of different serious inflammatory and —for example, the plasminogen system most likely is a driver of the devastating lung damage seen in COVID-19," said study co-leader and structural biologist Prof James Whisstock.


Explore further

Solving the riddle of superbug toxin damage to gut

More information: M.M. Awad et al, Human Plasminogen Exacerbates Clostridioides difficile Enteric Disease and Alters the Spore Surface, Gastroenterology (2020). DOI: 10.1053/j.gastro.2020.06.032
Journal information: Gastroenterology

Provided by Monash University
Citation: Superbug impact on the gut (2020, June 25) retrieved 14 July 2020 from https://medicalxpress.com/news/2020-06-superbug-impact-gut.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
2 shares

Feedback to editors

User comments