Risk for COVID-19 increased for adults taking PPIs

Risk for COVID-19 increased for adults taking PPIs

(HealthDay)—Adults taking proton pump inhibitors (PPIs) have an increased risk for having a positive COVID-19 test, with evidence of a dose-response relationship, according to a study published online July 7 in preprint format in the American Journal of Gastroenterology.

Christopher V. Almario, M.D., from Cedars-Sinai Medical Center in Los Angeles, and colleagues examined whether use of PPIs increases the odds of acquiring COVID-19 among community-dwelling Americans who were surveyed from May 3 to June 24, 2020.

The researchers found that 6.4 percent of the 53,130 participants reported a positive COVID-19 test. Compared with those not taking PPIs, individuals using PPIs up to once daily or twice daily had significantly increased odds for reporting a positive COVID-19 test (odds ratios, 2.15 and 3.67, respectively). Risk was not elevated for individuals taking histamine-2 receptor antagonists.

"The highest risk is seen among individuals taking PPIs twice daily—a common practice in both primary and secondary care—as they are nearly four-times more likely to report COVID-19 positivity when compared to those not on PPIs," the authors write. "Since meta-analysis reveals that twice daily PPIs do not offer clinically meaningful benefits over once daily dosing for , our findings further emphasize that PPIs should only be used when clinically indicated at the lowest effective dose."

Several authors disclosed financial ties to the pharmaceutical and health care industries.


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Citation: Risk for COVID-19 increased for adults taking PPIs (2020, July 13) retrieved 4 August 2020 from https://medicalxpress.com/news/2020-07-covid-adults-ppis.html
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