Predictors of amyloid-β deposits identified in oldest old

Predictors of amyloid-β deposits identified in oldest old

(HealthDay)—Predictors of amyloid-β (Aβ) deposition have been identified in the oldest old, according to a study published online July 22 in Neurology.

Beth E. Snitz, Ph.D., from the University of Pittsburgh, and colleagues examined long-term predictors of avoiding Aβ deposition in a in the oldest old. Beginning in 2010, 100 former participants of the Gingkgo Evaluation of Memory Study completed biannual Pittsburgh Compound B (PiB)-positron emission tomography imaging and annual clinical-cognitive evaluations.

Participants had a mean age of 92 years at the last cognitive evaluation. The researchers found that the APOE*2 allele predicted last Aβ status. Cognitive status was predicted by baseline cognition. Among Aβ-positive participants only, predictors of cognitive status were baseline cognitive test scores and smoking history. Longitudinal Aβ increase was predicted by baseline pulse pressure; less was predicted by paid work engagement and .

"As advanced aging increases in developed countries and worldwide, well-designed studies are needed to better understand variability of cognitive outcomes in the 10th decade of life, particularly to determine and confirm modifiable risk and protective factors," the authors write.

One author disclosed financial ties to the biopharmaceutical industry; one author is a co-inventor of Pittsburgh Compound B.

More information: Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Journal information: Neurology

Copyright © 2020 HealthDay. All rights reserved.

Citation: Predictors of amyloid-β deposits identified in oldest old (2020, July 23) retrieved 3 February 2023 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Cardiovascular risk factors linked to faster cognitive decline in midlife


Feedback to editors