Point-of-care biomarker assay for traumatic brain injury

Point-of-care biomarker assay for traumatic brain injury
Credit: Mary Ann Liebert, Inc., publishers

Intracranial abnormalities on CT scan in patients with traumatic brain injury (TBI) can be predicted by glial fibrillary acidic protein (GFAP) levels in the blood. These interim findings from the TRACK-TBI study are published in the peer-reviewed Journal of Neurotrauma.

GFAP's was significantly better than that of the S100B biomarker, to which it was compared. S100B is approved for use in Europe, but not in the U.S.

"GFAP substantially outperformed S100B as a TBI diagnostic biomarker of positive head CT scans," state David Okonkwo, MD, Ph.D., University of Pittsburgh Medical Center, Amy Markowitz, JD, University of California, San Francisco, and coauthors.

"Our results validate a point-of-care platform prototype GFAP assay that delivers results in minutes (<15 min) versus hours for the current FDA-cleared assay," state the authors.

"This is a particularly important study with major implications for the diagnosis and prognoses of . The large sample size and the rigorous inclusion criteria increase the impact of the reported study, which strongly reaffirms the utility of GFAP as a diagnostic marker for CT-detected lesions. It also demonstrates the utility of a point-of-care approach. As noted by the authors, the reported studies demonstrate GFAP's utility across the spectrum of TBI, evaluated over a relatively prolonged posttraumatic time course," says John Povlishock, Ph.D., Editor-in-Chief of Journal of Neurotrauma.


Explore further

Blood test to detect traumatic brain injury could reduce unnecessary CT scans

More information: David O. Okonkwo et al, Point-of-Care Platform Blood Biomarker Testing of Glial Fibrillary Acidic Protein versus S100 Calcium-Binding Protein B for Prediction of Traumatic Brain Injuries: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study, Journal of Neurotrauma (2020). DOI: 10.1089/neu.2020.7140
Journal information: Journal of Neurotrauma

Citation: Point-of-care biomarker assay for traumatic brain injury (2020, September 16) retrieved 20 September 2020 from https://medicalxpress.com/news/2020-09-point-of-care-biomarker-assay-traumatic-brain.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
2 shares

Feedback to editors

User comments