Immune cells found in the brain are behind the depression experienced in inflammation

Immune cells found in the brain are behind the depression experienced in inflammation
David Engblom, professor at Linköping University, Sweden. Credit: Thor Balkhed/Linköping University

Special immune cells found in the brain, microglia, play a key role in the processes that make you feel uneasy and depressed in correlation with inflammation. This is the conclusion of a study using mice carried out by researchers at Linköping University, Sweden. The results have been published in the scientific journal Immunity, and suggest that microglial cells contribute to the negative mood experienced during several neurological diseases, and maybe also depression.

David Engblom's research group at Linköping University has spent many years looking at why inflammation in the body, such as a common cold or influenza, causes us to feel poorly and despondent, and why we feel like retiring into our shell. The activity of the immune system influences nerve in some way. However, normal cells of the immune system are not able to get into the brain: it is sensitive and must be protected. Instead, the brain has its own special immune cells: microglial cells.

Previous research has shown that microglial cells are activated in several , such as Alzheimer's , Parkinson's disease and stroke. People who are affected by these conditions also often fall into a negative . Other previous research has suggested that inflammatory processes also play a role in the development of depression. This led the researchers behind the new study to examine more closely whether microglial cells are involved in regulating mood during inflammation.

"The study showed that animals feel sick and uneasy when we activate the microglial cells. We demonstrate that two , interleukin-6 and prostaglandin E2, are particularly important in these processes. It's not surprising that these signal substances are central, but we were a bit surprised that it is the microglial cells that release these molecules," says David Engblom, professor in the Department of Biomedical and Clinical Sciences (BKV) at Linköping University.

During inflammation, many processes are initiated in several . One of the challenges in determining the role played by a specific cell type in the body, therefore, is to isolate its effects. In this study, the scientists used a technique known as chemogenetics, which enabled them to switch on the activity specifically in microglial cells in . The researchers activated the microglial cells when the mice were being kept in a certain type of surroundings. The mice subsequently avoided this type of surroundings, which the researchers interpret as showing that the animals disliked the experience. The mice also became less interested in a sweet solution, which they normally find very tempting.

In order to investigate whether the microglial cells are an important link between the immune system and mood, the researchers investigated what happened when microglial cells are inhibited. When the microglial cells were not available for activation, the mice did not feel poorly, even when they had inflammation. This reinforces the idea that these cells are necessary for the process.

"Our results show that the activation of is sufficient to create aversion and in mice. It's natural to suggest that similar processes take place in several human diseases. It's not unlikely that activated microglia contribute to the discomfort and depressed mood in people with inflammatory and neurological diseases," says David Engblom.

If further research demonstrates that the biological mechanism described in the study functions in the same way in humans, it may be possible in the long run to reduce symptoms of depression by inhibiting this mechanism.


Explore further

Maternal immune activation induces sustained changes in fetal microglia motility

More information: Anna M. Klawonn et al. Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons, Immunity (2021). DOI: 10.1016/j.immuni.2020.12.016
Journal information: Immunity

Citation: Immune cells found in the brain are behind the depression experienced in inflammation (2021, January 25) retrieved 5 March 2021 from https://medicalxpress.com/news/2021-01-immune-cells-brain-depression-experienced.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
134 shares

Feedback to editors

User comments