Auditory brainstem pathways do not develop properly without microglia

Auditory brainstem pathways do not develop properly without microglia
Effects of BLZ945 treatment withdrawal (allowing microglia to return) on IBA1 expression (sign of microglia) in the auditory brainstem. Credit: Milinkeviciute et al., eNeuro 2021.

Auditory pathways in the brainstem do not fully mature without microglia clearing away extra cell connections. This crucial function occurs even when pruning by microglia is delayed, according to new research published in eNeuro.

Sensitive requires precise connections between neurons in the auditory brainstem. Early in development, support cells called microglia prune away unnecessary connections and encourage others to expand. Microglia finish their job around two weeks after birth, but the rigidity of this developmental timeframe is unknown.

Milinkeviciute et al. eliminated microglia from the brains of newborn mice using a drug. They stopped the treatment after 10 days, and microglia returned to the . Initially, the mice with delayed microglia development had more synaptic connections and less sensitive hearing than the controls. The repopulated microglia corrected these issues by the time the mice were seven weeks old.

These results demonstrate the crucial role of in hearing development, even when the timing of their activity is delayed.

More information: Auditory Brainstem Deficits From Early Treatment With a CSF1R Inhibitor Largely Recover With Microglial Repopulation, eNeuro, DOI: 10.1523/ENEURO.0318-20.2021

Citation: Auditory brainstem pathways do not develop properly without microglia (2021, February 8) retrieved 26 February 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Immune cells sculpt circuits in the brain


Feedback to editors