Signals from muscle protect from dementia

Signals from muscle protect from dementia
Research in the lab of Fabio Demontis, PhD, of Developmental Neurobiology, used immunostaining and confocal microscopy on fruit fly brain and retina cells to show that Amyrel reduces the accumulation of protein aggregates seen in red and yellow. Credit: St. Jude Children's Research Hospital

How do different parts of the body communicate? Scientists at St. Jude are studying how signals sent from skeletal muscle affect the brain.

The team studied and cutting-edge brain cell models called organoids. They focused on the signals muscles send when stressed. The researchers found that stress signals rely on an enzyme called Amyrel amylase and its product, the disaccharide maltose.

The scientists showed that mimicking the can protect the brain and retina from aging. The signals work by preventing the buildup of misfolded protein aggregates. Findings suggest that tailoring this signaling may potentially help combat neurodegenerative conditions like age-related dementia and Alzheimer's disease.

"We found that a stress response induced in muscle could impact not only the muscle but also promote protein quality control in distant tissues like the brain and retina," said Fabio Demontis, Ph.D., of St. Jude Developmental Neurobiology. "This was actually protecting those tissues during aging."

Cell Metabolism published a report on this work.


Explore further

Research reveals how muscles talk to the brain to regulate feeding behavior

More information: Mamta Rai et al, Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging, Cell Metabolism (2021). DOI: 10.1016/j.cmet.2021.03.005
Journal information: Cell Metabolism

Citation: Signals from muscle protect from dementia (2021, March 26) retrieved 18 May 2021 from https://medicalxpress.com/news/2021-03-muscle-dementia.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
34 shares

Feedback to editors

User comments