Genomic test could help predict aggressive disease in men newly diagnosed with prostate cancer

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After a biopsy comes back positive for prostate cancer, patients and their doctors are often left with a choice between taking a watch-and-wait approach, known as active surveillance, or proceeding with surgery or radiation.

And identifying which patients will benefit from more immediate and aggressive treatment isn't always clear.

A new, University of Michigan-led study analyzing data from more than 850 patients across the state of Michigan, however, found a commercially available genomic known as Decipher Biopsy may help identify patients who are at high risk of progression."We have long needed better tools to reduce the uncertainty of these initial treatment decisions," said study first author Randy Vince, Jr., M.D., M.S., an oncology fellow at U-M.Veracyte, the company that makes the tests, did not sponsor the study or play a role in the analysis.

Between February 2015 and October 2019, 855 patients participating in the state Michigan Urological Surgery Improvement Collaborative registry underwent testing with the Decipher Biopsy test after being diagnosed with cancer— one of the first real-world, of a commercially available genomic test designed to aid in decision-making after an initial diagnosis.

The research team found the data supported the clinical utility of the Decipher Biopsy test, according to findings published in Prostate Cancer and Prostatic Diseases.

The analysis found men with a high Decipher score who were placed on active surveillance had a shorter time before active treatment was needed, Vince said. And for those who underwent surgery to remove the , high scores were associated with shorter time until their (PSA) levels went up again or when they were put on anti-androgen therapy.

Meanwhile, G-MAJOR, an ongoing clinical trial led by study senior author Todd Morgan, M.D., a member of the U-M Rogel Cancer Center who heads the division of urologic oncology at U-M, is evaluating the use of Decipher and other similar molecular classifying tests in lower-risk to more fully evaluate their clinical utility. The trial is also being led by study co-author Daniel Spratt, M.D., formerly of U-M and now chair of the Department of Radiation Oncology at Case Western Reserve University.The statewide collaborative, known as MUSIC, is managed by the MUSIC Coordinating Center, which is housed at U-M. Support for MUSIC is provided by Blue Cross and Blue Shield of Michigan.

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More information: Randy A. Vince et al, Impact of Decipher Biopsy testing on clinical outcomes in localized prostate cancer in a prospective statewide collaborative, Prostate Cancer and Prostatic Diseases (2021). DOI: 10.1038/s41391-021-00428-y
Citation: Genomic test could help predict aggressive disease in men newly diagnosed with prostate cancer (2021, July 27) retrieved 27 September 2022 from
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