New genetic risk factors for arrhythmia discovered

New genetic risk factors for arrhythmia discovered
Associations between polygenic susceptibility to BrS and common cardiovascular diseases and traits. Credit: Nature Genetics (2022). DOI: 10.1038/s41588-021-01007-6

A recent study published in Nature Genetics identified 10 new genetic regions associated with Brugada syndrome, a cardiac arrhythmia disorder associated with sudden death in young adults.

The findings expand possibilities for predictive risk scoring and provide new targets for therapeutic study, according to Alfred George, Jr., MD, chair and the Alfred Newton Richards Professor of Pharmacology and a co-author of the study.

"Prior to this work, there were only two genomic regions associated with Brugada syndrome risk that were identified by genome-wide studies. Data from the new study greatly expands this to 12 regions with a total of 21 genetic signals to better explain risk for Brugada syndrome," George said. "The results also provide the basis for a that can be used to assess risk in individuals."

Brugada syndrome (BrS) is a characterized by life-threatening irregular heart beating. Approximately 20% of cases possess rare genetic variants in a gene that codes for a cardiac sodium channel that mediates the heart beat, but other proven susceptibility genes were largely unknown.

To identify the new , scientists constructed a of nearly 3,000 unrelated individuals with BrS from 12 countries, then performed genome-wide association analysis and compared results to 10,000 individuals without BrS. The investigators found ten new genetic regions consisting of 21 different genetic markers associated with BrS.

Many of these regions are located on chromosome 3, containing genes that are known to encode two , SCN5A and SCN10A. Further, other genetic regions included several genes encoding cardiac developmental transcription factors, suggesting that modulation of these sodium channels through transcription is an important mechanism in BrS.

Investigators at Northwestern then used CRSIPR-Cas9 gene editing to knock out one important cardiac microtubule gene—MAPRE2—in , finding that the gene is critical for stabilizing microtubule networks in cardiomyocytes, the cells that contract to control beating of the heart. In the absence of MAPRE2, sodium channels in cardiomyocytes are less active.

The plethora of genetic associations revealed by this study indicate that BrS has a complex origin, according to George.

"The work further supports the notion that BrS is not a simple monogenic disease, but rather a genetically complex susceptibility to cardiac arrhythmia," George said.

Further, the size of this analysis means a polygenic risk score for BrS could be helpful in quantifying risk of sudden cardiac death in other arrhythmia conditions, according to the authors.

More information: Julien Barc et al, Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility, Nature Genetics (2022). DOI: 10.1038/s41588-021-01007-6

Journal information: Nature Genetics

Citation: New genetic risk factors for arrhythmia discovered (2022, March 31) retrieved 7 December 2023 from
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