Pediatric-onset inflammatory bowel disease may up cancer risk

Pediatric-onset inflammatory bowel disease may up cancer risk

Patients with pediatric-onset inflammatory bowel disease (IBD) may have an increased risk for developing cancer, particularly gastrointestinal cancers, according to a meta-analysis published online March 1 in JAMA Network Open.

Rahma Elmahdi, M.D., Ph.D., from the Center for Molecular Prediction of Inflammatory Bowel Disease at Aalborg University in Denmark, and colleagues conducted a systematic literature review and to evaluate the relative rate of cancer among patients with pediatric-onset IBD.

Based on five eligible population-based studies (19,812 individuals), the researchers identified 715 cases of cancer. Compared with the general population, there was a more than doubled increased rate of cancer among patients with pediatric-onset IBD (pooled relative rate [pRR], 2.46), including Crohn disease (pRR, 2.03) and ulcerative colitis (pRR, 2.61). This increase was driven by an increased rate of liver (pRR, 55.45), colorectal (pRR, 20.29), and small bowel (pRR, 16.20) cancers. Four studies revealed incidence rates ranging from 1.0 to 3.3 cases per 1,000 person-years among patients with pediatric-onset IBD.

"These results suggest that there is a greater than twofold increased rate of cancer among patients with pediatric-onset IBD compared with general pediatric populations, due primarily to an increased rate of ," the authors write. "Identifying variables that modulate in would be valuable for targeting prevention and screening."


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More information: Rahma Elmahdi et al, Development of Cancer Among Patients With Pediatric-Onset Inflammatory Bowel Disease, JAMA Network Open (2022). DOI: 10.1001/jamanetworkopen.2022.0595
Journal information: JAMA Network Open

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Citation: Pediatric-onset inflammatory bowel disease may up cancer risk (2022, March 11) retrieved 5 July 2022 from https://medicalxpress.com/news/2022-03-pediatric-onset-inflammatory-bowel-disease-cancer.html
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