New minimally invasive treatments offer hope for patients with severe heart valve disease

New minimally invasive treatments offered in NHCS offer hope for patients with severe heart valve disease
Illustrates a normal valve versus tricuspid valve regurgitation. Credit: National Heart Centre Singapore

National Heart Center Singapore (NHCS) now offers two new procedures—TricValve and TriClipTM—bringing a comprehensive suite of treatment options, ranging from medication therapies, minimally invasive (percutaneous or transcatheter) procedures, and surgical treatments to repair or replace the damaged valve, to patients with severe tricuspid valve problems. Being the early adopter for advanced valve therapies, NHCS was the first in Asia to introduce Transcatheter Aortic Valve Implantation (TAVI), also known as Percutaneous Aortic Valve Replacement (PAVR) in 2009, and also to perform minimally invasive heart valve repair using the MitraClip system in 2011.

In the past, treatment of severe tricuspid regurgitation was limited to medications to alleviate symptoms, and surgery to repair or replace the valve. For some patients, operative risk was high and the condition was left largely undertreated. Now, with the advancement and availability of less invasive transcatheter valve therapies, such as TricValve and TriClipTM, selected patients who are unsuitable for might be able to get their condition treated. Although these are relatively new procedures for which long-term data on outcomes are still being studied, they are additional options for patients with significant symptoms who are deemed unsuitable for surgery.

What is tricuspid regurgitation?

Tricuspid regurgitation (also known as leaky valve) occurs when the valve between the two right heart chambers (atrium and ventricle) does not close properly, causing blood to leak backwards. When the regurgitation becomes severe, it can lead to congestion in various organs such as the liver and the kidney, and affect their function. Severe tricuspid regurgitation has been shown to be associated with significant mortality and morbidity.

New procedures to treat severe tricuspid regurgitation:

  1. TricValve Transcatheter Bicaval Valves System: The procedure involves inserting 2 bioprosthetic (tissue) valves known as the TricValve into the large veins close to the heart, without the need to remove the defective tricuspid valve. NHCS has successfully performed three cases to-date and is the first center in Singapore to offer this treatment.
  2. TriClipTM Transcatheter Tricuspid Valve Repair System: The TriClipTM procedure builds upon the successful MitraClip system. It serves to repair the leaky tricuspid valves by delivering a clip system to the heart through the femoral vein in the leg, and clipping a portion of the leaflets of the tricuspid valve to reduce backflow of blood. NHCS has successfully performed the first case in Southeast Asia.

Hope for patients with severe tricuspid regurgitation

In 2020, when 52-year old Mr. Tan experienced shortness of breath, leg swelling and abdominal bloating, little did he know he had severe tricuspid regurgitation. As Mr. Tan has an underlying condition known as Marfan syndrome that affects the aorta and had undergone several surgeries, he is considered high risk for tricuspid valve surgery. An earlier attempt to treat the tricuspid regurgitation could not improve his condition. Fortunately, the availability of TricValve provided him an alternative treatment, enabling him to recover faster and improve his quality of life.

"We strive to constantly look at advancing treatments to improve patient care and bring better health outcomes. The introduction of these new transcatheter valve therapies provide viable treatments for severe tricuspid that will help patients to alleviate their symptoms, shorten and , and more importantly, improve their quality of life," said Associate Professor Yeo Khung Keong, Deputy Chief Executive Officer (Data Science & Innovation) and Senior Consultant, Department of Cardiology, NHCS and the lead physician for TricValve and TriClipTM procedures.

"During the TricValve procedure, two bioprosthetic valves are inserted through the blood vessel of the patient's leg and placed in the venous system close to the right heart chambers. The valves then self-expand in place and work to reduce the backflow of blood and pressure on the other organs in the body. There is no need to remove or repair the original tricuspid valve, allowing for future interventions if required," explained Dr. Wong Ningyan, consultant, Department of Cardiology.

Prof Yeo adds, "The TriClipTM system, on the other hand, works to repair the leaky tricuspid valve. The clip system is inserted into the femoral vein in the leg and delivered to the heart to clip the leaflets of the damaged together, effectively reducing backflow of blood and relieving patient's symptoms."

More information: Yan Topilsky et al, Clinical Outcome of Isolated Tricuspid Regurgitation, JACC: Cardiovascular Imaging (2014). DOI: 10.1016/j.jcmg.2014.07.018

Provided by SingHealth
Citation: New minimally invasive treatments offer hope for patients with severe heart valve disease (2022, May 11) retrieved 24 May 2024 from
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