Repurposing existing drugs to fight new COVID-19 variants

Repurposing existing drugs to fight new COVID-19 variants
Graphical abstract. Credit: iScience (2022). DOI: 10.1016/j.isci.2022.105068

Finding new ways to treat the novel coronavirus and its ever-changing variants has been a challenge for researchers, especially when the traditional drug development and discovery process can take years. A Michigan State University researcher and his team are taking a hi-tech approach to determine whether drugs already on the market can pull double duty in treating new COVID variants.

"The COVID-19 virus is a challenge because it continues to evolve," said Bin Chen, an associate professor in the College of Human Medicine. "By using and really , we can repurpose old drugs for new uses."

Chen built an international team of researchers with expertise on topics ranging from biology to computer science to tackle this challenge. First, Chen and his team turned to publicly available databases to mine for the unique coronavirus gene expression signatures from 1,700 host transcriptomic profiles that came from patient tissues, cell cultures and mouse models. These signatures revealed the biology shared by COVID-19 and its variants.

With the virus's signature and knowing which genes need to be suppressed and which genes need to be activated, the team was able to use a computer program to screen a drug library consisting of FDA-approved or investigational drugs to find candidates that could correct the expression of signature genes and further inhibit the coronavirus from replicating.

Chen and his team discovered one novel candidate, IMD-0354, a drug that passed phase I for the treatment of atopic dermatitis. A group in Korea later observed that it was 90-fold more effective against six COVID-19 variants than remdesivir, the first drug approved to treat COVID-19. The team further found that IMD-0354 inhibited the virus from copying itself by boosting the immune response pathways in the host cells. Based on the information learned, the researchers studied a prodrug of IMD-0354 called IMD-1041. A prodrug is an inactive substance that is metabolized within the body to create an active drug.

"IMD-1041 is even more promising as it is orally available and has been investigated for , a group of lung diseases that block airflow and make it difficult to breathe," Chen said. "Because the structure of IMD-1041 is undisclosed, we are developing a new artificial intelligence platform to design novel compounds that hopefully could be tested and evaluated in more advanced animal models."

The research was published in the journal iScience.

More information: Jing Xing et al, Deciphering COVID-19 host transcriptomic complexity and variations for therapeutic discovery against new variants, iScience (2022). DOI: 10.1016/j.isci.2022.105068

Journal information: iScience
Citation: Repurposing existing drugs to fight new COVID-19 variants (2022, September 29) retrieved 20 July 2024 from
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