Research suggests gut microbiome plays a role in lifestyle's effects on dementia risk

Research suggests gut microbiome plays a role in lifestyle's effects on dementia risk
Summary of intervention results. Dashed arrows denote mixed evidence for cognitive effects. LPS = lipopolysaccharide; BDNF = brain-derived neurotrophic factor; PFC = prefrontal cortex; AD = Alzheimer’s disease; LDLR−/− = low-density lipoprotein receptor knockout mice; SAMP8 = senescenceaccelerated mouse-prone 8; PUFAs = polyunsaturated fatty acids, SCFAs = short-chain fatty acids; HPA axis = hypothalamic–pituitary–adrenal axis, HIIT = highintensity interval training. Credit: The Journals of Gerontology: Series A (2022). DOI: 10.1093/gerona/glac166

The gut microbiome may play a role in how diet and exercise affect brain health and dementia risk, suggests a recent Baycrest study. This knowledge could help scientists and clinicians optimize strategies to prevent dementia.

Lifestyle interventions to reduce often include diet and exercise, which are known to affect the —the community of bacteria and other microorganisms that live in our gut.

"We know that imbalances in the microbiome are associated with impaired cognition," says Noah Koblinsky, lead author of the study, Exercise Physiologist and Project Coordinator at Baycrest's Rotman Research Institute (RRI).

"However, we don't know much about the role of the microbiome when we use , such as diet and exercise, to support health. Can we tailor lifestyle interventions to specifically target the gut microbiome, and will this help to optimize their effects on cognition? In this review study, we aimed to address this gap in knowledge."

To this end, Koblinsky and his team reviewed all of the existing research on diet and exercise interventions that looked at both the microbiome and brain health. The study was published in the Journals of Gerontology: Series A.

They found that the gut microbiome does appear to play a role in how diet and exercise affect brain health, though more research is needed to fully understand how.

Diet studies showed a large impact of diet on the microbiome, with foods associated with a Mediterranean-style eating pattern (for example, fiber and healthy fats) appearing to have the greatest benefit to a healthy gut microbiome and brain. One study of 1,200 older adults looked at the impact of diet on both cognition and the microbiome.

Half of the participants were asked to follow a Mediterranean-style diet for 12 months, while the other half were not. Those in the Mediterranean diet group showed significant improvements in cognition. As well, those who followed the diet more closely had healthier microbiomes associated with better brain health.

In another study, researchers used antibiotics to "kill off" the gut microbiome in a sample of rats. They then gave those rats microbiome (fecal) transplants from rats that had either been fed an unhealthy diet or a healthy diet. The rats that received the transplant from the unhealthy diet group showed worse memory performance, as well as inflammation in the intestines and brain.

These findings support the idea that the microbiome plays a role in the way diet impacts brain health.

The researchers found fewer studies looking at exercise. However, those that did suggest that starting exercise, specifically aerobic exercise, can lead to changes in the gut microbiome and brain health at the same time.

This area of research is still in its infancy, and the majority of the studies that the researchers reviewed looked at rodents and singular dietary components (for example, fiber) rather than whole diet patterns (like the Mediterranean diet). Overall, the researchers found a clear need for more studies on whole diet and exercise interventions looking at both the microbiome and brain health, particularly in older adults at risk of dementia.

The researchers are now launching a and exercise randomized controlled trial and are looking to secure funding to include analysis of microbiome changes.

"By better understanding how changes to the gut microbiome affect the relationship between lifestyle and , we can strengthen existing lifestyle interventions and create new strategies to reduce dementia risk, helping everywhere age fearlessly," says Dr. Nicole Anderson, Senior Scientist at the RRI, Associate Scientific Director of Baycrest's Kimel Family Center for Brain Health and Wellness, and the senior author on this study.

More information: Noah D Koblinsky et al, The Role of the Gut Microbiome in Diet and Exercise Effects on Cognition: A Review of the Intervention Literature, The Journals of Gerontology: Series A (2022). DOI: 10.1093/gerona/glac166

Citation: Research suggests gut microbiome plays a role in lifestyle's effects on dementia risk (2022, October 11) retrieved 17 July 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Nutritionally balanced and whole-food-based, fiber-rich diet is beneficial to gut health


Feedback to editors