The ingredients used in the dietary supplement are L-tyrosine, acetyl L-carnitine HCL, sodium citicoline, alpha-GPC, taurine, caffeine, mango leaf extract, and huperzia serrata leaf extract. Credit: University of Granada

The PROFITH CTS-977 research group from the University of Granada (UGR) has tested the effects of a multi-ingredient dietary nootropic on concentration levels and cognitive performance. Nootropics are cognitive enhancers that have traditionally been used in the treatment of cognitive pathologies.

Leading this study was Lucas Jurado Fasoli—a researcher from the Scientific Unit of Excellence in Exercise, Nutrition and Health (UCEENS) at the Sport and Health Joint University Institute (iMUDS). He explains that, traditionally, nootropics have been drugs, with their corresponding side-effects.

"To address the issue of potential side-effects, different dietary nootropics have emerged as an alternative way to enhance . And these, as is the case in this study, are used by healthy individuals in activities such as preparing for competitive exams or video-game competitions," explains Jurado Fasoli.

The results of the study showed that the acute intake of this multi-ingredient nootropic decreases the response time across different cognitive tests: in processing speed, inhibitory control, working memory, and cognitive flexibility. It also increases accuracy in tests involving processing speed, inhibitory control, and cognitive flexibility.

These results were accompanied by an increase in and a decrease in and depression. And, importantly, the favorable effects of this nootropic did not appear to have any effect on the heart-rate of participants.

A sample comprising 26 (50:50 male/female, with an average age of 25) participated in the study. They were required to undertake various cognitive tests twice, separated by 48 hours, having ingested either the multi-ingredient dietary nootropic or a placebo (randomized and triple-blinded across the sample).

Thirty minutes after ingestion, measurements were taken of processing speed, inhibitory control, working memory, cognitive flexibility, creativity, and verbal fluency. Different emotions were also evaluated and the participants' heart-rate was recorded while they undertook the tests.

The research is published in Frontiers in Nutrition.

The results of this study could have multiple practical applications, especially in situations in which a rapid response, combined with high precision, is required in response to different stimuli. Such areas of application could include, for instance, video games or e-sports; occupations with a heavy cognitive load, such as piloting aircraft; the Armed Forces; computer programming; and activities that involve intensified cognitive demands, such as studying for competitive exams or research.

More information: María Medrano et al, Acute Effect of a Dietary Multi-Ingredient Nootropic as a Cognitive Enhancer in Young Healthy Adults: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial, Frontiers in Nutrition (2022). DOI: 10.3389/fnut.2022.858910