Does maternal obesity during pregnancy impact offspring's liver and skeletal muscle metabolism?

Does maternal obesity during pregnancy impact offspring's liver and skeletal muscle metabolism?
Credit: The FASEB Journal (2022). DOI: 10.1096/fj.202201473R

A recent study in The FASEB Journal has identified metabolic perturbations in the liver and skeletal muscle of young nonhuman primates on normal diets whose mothers were obese during pregnancy.

For the study, were obtained from 19 post-pubertal offspring of mothers who were fed a Western diet and were obese during pregnancy, and from 13 control animals born to non-obese mothers fed a standard diet. All offspring ate a healthy chow diet after weaning. Investigators identified 58 metabolites significantly altered in liver and 46 in skeletal muscle of the offspring of mothers with obesity during pregnancy, with 8 metabolites shared between both tissues. Several were identified from these dysregulated metabolites. These differences in were not seen in taken from the animals.

"This study is exciting for two reasons: First it shows that exposure to an unhealthy environment in utero has long-term health consequences, and different organs and tissues are affected in different ways." said corresponding author Michael Olivier, Ph.D., of Wake Forest University School of Medicine. "Second, our analysis suggests you cannot just analyze blood samples to understand what is happening in the liver or muscle."

More information: Isaac Ampong et al, Maternal obesity alters offspring liver and skeletal muscle metabolism in early post‐puberty despite maintaining a normal post‐weaning dietary lifestyle, The FASEB Journal (2022). DOI: 10.1096/fj.202201473R

Journal information: FASEB Journal
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Citation: Does maternal obesity during pregnancy impact offspring's liver and skeletal muscle metabolism? (2022, November 23) retrieved 18 July 2024 from https://medicalxpress.com/news/2022-11-maternal-obesity-pregnancy-impact-offspring.html
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