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Development of first smart intraocular lens technology, capable of early-stage dementia diagnosis

Development of first smart intraocular lens technology, capable of early-stage dementia diagnosis
Graphical abstract. Credit: Bioactive Materials (2022). DOI: 10.1016/j.bioactmat.2022.11.010

A smart intraocular lens that can be inserted into the eye to diagnose Alzheimer's has been developed for the first time in Korea.

The Korea Institute of Machinery and Materials, an institute under the jurisdiction of the Ministry of Science and ICT, through joint research with Yonsei University, Yonsei University College of Medicine Yongin Severance Hospital, and Gangnam Severance Hospital, has succeeded in developing an intraocular implant that can diagnose Alzheimer's, a , at its early stages. The results of this research study were published in Bioactive Materials.

Principal Researcher JaeJong Lee of the KIMM Department of Nano Manufacturing Technology, Yonsei University Professor Won-gun Koh, Severance Hospital Ophthalmology Professors Hyung Keun Lee and Professor Yong-woo Ji focused on the characteristics of the eye, which is directly connected to the brain, and detected various biomarkers through trilateral cooperation among the KIMM, Yonsei University, and Severance Hospital. Through their research efforts, they developed an implantable biosensing system by mounting a bioresponsive hydrogel-based sensing module capable of detecting various biomarkers on an to express a signal in a moiré pattern.

KIMM develops Korea's first smart intraocular lens technology, capable of early-stage dementia diagnosis
Lens used in the development of smart intraocular lenses. Credit: Korea Institute of Machinery and Materials (KIMM)

When the hydrogel pattern, to which the antibody is bound, reacts with the target , it contracts. The target biomarker is then detected using changes in the moiré signal, which are generated when the hydrogel pattern, which becomes narrower by the contraction response, overlaps with the designated reference grid. By using a moiré signal, detection is possible with much greater sensitivity than that of other methods that directly detect change in the hydrogel pattern.

Furthermore, unlike traditional biosensors, the moiré signal-based biomarker detection method can directly detect biomarkers without using electrochemical or fluorescent labels. Since this method does not require or a , one of its advantages is that it can be implanted within the body.

Principal Researchers JaeJong Lee and Geehong Kim of the KIMM Department of Nano Manufacturing Technology stated that the development of this technology is significant in that it can reduce by diagnosing various neurological diseases, including dementia, which is one of the most common of such diseases that lead to social issues. They added that KIMM will continue to promote further research on this technology until it can be made available for commercial use.

More information: Semin Kim et al, Real-time and label-free biosensing using moiré pattern generated by bioresponsive hydrogel, Bioactive Materials (2022). DOI: 10.1016/j.bioactmat.2022.11.010

Provided by National Research Council of Science & Technology
Citation: Development of first smart intraocular lens technology, capable of early-stage dementia diagnosis (2023, January 12) retrieved 27 March 2023 from
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