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Target the microbiome to improve child undernutrition, say researchers

Target the microbiome to improve child undernutrition, say researchers
Compositional and functional maturation of the gut microbiome of 335 infants from rural Zimbabwe from 1–18 months of age. PCoA of Bray-Curtis distances of species (a; PERMANOVA; two-sided, p < 0.001) and metagenomic pathways (b; PERMANOVA; two-sided, p < 0.001) colored by age category. The top 20 features and model pseudo-R2 from XGBoost models predicting age using species (c) or pathways (d) are ranked by scaled feature importance and relative abundance(0–1) plotted by age (e, f) to visualize taxonomic and functional microbiome succession from 1–18 months of age. n = 875 samples. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-36135-6

Research led by Queen Mary University of London suggests that nutritional interventions used to tackle child undernutrition in lower and middle-income countries should target gut microbiome development, rather than just human nutritional needs, to more effectively improve child growth and development.

The research, published today in Nature Communications, found that improvements in nutrition and household sanitation of children in rural Zimbabwe have little effect on a child's and thus, growth and development, and that genetic function of gut microbes in —rather than the types of microbes present in the gut—can predict how well a child is growing or will grow in the coming months.

This is one of the first studies to examine how the gut develops in low- and . The gut microbiome is a collective term for the trillions of different microbes living within the human gut, which are essential for developmental processes in early life, such as building immunity, hormone production and metabolism of certain nutrients.

Until now, most of the research on the gut microbiome's role in is from high-income settings, not in low- and middle-income countries, where childhood infections and mortality are much higher, and where undernutrition affects more than 1 in 5 children.

The study was carried out by researchers from Queen Mary University of London, the University of British Columbia and Devil's Staircase Consulting, Canada. The researchers used metagenome sequencing technologies to analyze the gut microbiome of 335 children from rural Zimbabwe, aged 1 to 18 months.

The children were given two interventions as part of The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) randomized control trial. The first intervention was improvement to infant and young-child feeding. This included providing a nutritional supplement called "nutributter" from 6-18 months of age. The second intervention was improvement to household water, sanitation, and hygiene. This started during pregnancy, and included building new pit latrines, handwashing stations, providing chlorinated drinking water and dedicated child playpens.

Surprisingly, the results showed that these interventions had very little effect on the children's gut microbiomes, suggesting that more intensive interventions are required to alter the microbes that colonize the infant gut in early life in these settings.

The researchers also found that genetic functions of the gut microbes, such as B vitamin metabolism, can predict how well a child is growing, or will grow, in the following months. As child growth is strongly associated with immune development, brain development and other developmental processes, this new microbiome data provides a new target for interventions to optimize these growth and developmental pathways in children at risk.

First author Dr. Ruairi Robertson from Queen Mary University of London said, "This study provides the with a very large resource of gut microbiome data from children in a rural, non-Western setting throughout , which will allow researchers around the world to analyze and compare with similar datasets from children in high-income settings."

"This study also provides important data for in low-and-middle income countries where early-life infections, diarrheal disease, and undernutrition are much more common."

More information: Ruairi C. Robertson et al, The gut microbiome and early-life growth in a population with high prevalence of stunting, Nature Communications (2023). DOI: 10.1038/s41467-023-36135-6

Journal information: Nature Communications

Citation: Target the microbiome to improve child undernutrition, say researchers (2023, February 14) retrieved 4 June 2023 from
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