This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

peer-reviewed publication

trusted source

proofread

New study: Type 2 diabetes drug could treat autoimmune disorders

New study: Type 2 diabetes drug could treat autoimmune disorders
Graphical abstract. Credit: Cell Metabolism (2023). DOI: 10.1016/j.cmet.2023.05.001

Swansea University researchers have found that a drug commonly used to treat type 2 diabetes can potentially be used in the treatment of autoimmune disorders.

Academics at the University's Faculty of Medicine, Health and Life Science have found that the drug, canagliflozin (also known as Invokana), could be used to treat such as and as it targets T-cells, which form an essential component of the immune system. Canagliflozin is a drug that controls in people with type 2 diabetes, however researchers have found an unexpected role for the drug involving the human immune system.

Existing research has reported that targeting T-cell metabolism in autoimmunity can lead to therapeutic benefits. T-cells are a type of white blood cell that help the body fight infections and diseases, but in autoimmune diseases they have been observed to attack healthy tissues.

The new study, published in the journal Cell Metabolism, found that canagliflozin dampens T-cell activation, suggesting that the drug could be repurposed as a treatment for T-cell driven autoimmunity.

Dr. Nick Jones, senior author who led the study said, "Our findings are significant as they provide the foundation for the clinical development of canagliflozin for the treatment of certain autoimmune diseases. As the drug is already widely used and has a known safety profile in humans, it could potentially reach clinic quicker than any new drugs developed and bring valuable benefits more swiftly to patients with autoimmune disorders."

Ben Jenkins, first author and postdoctoral researcher at Swansea said, "Identifying new roles for drugs that are currently being used in other disease settings is an exciting area of research. Given that our research primarily targets the metabolism of immune cells, we hope that the potential therapeutic benefits of our findings are applicable to a wide range of conditions."

The researchers are hopeful that canagliflozin will enter a clinical trial to treat certain autoimmune disorders in the future.

More information: Benjamin J. Jenkins et al, Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity, Cell Metabolism (2023). DOI: 10.1016/j.cmet.2023.05.001

Journal information: Cell Metabolism
Provided by Swansea University
Citation: New study: Type 2 diabetes drug could treat autoimmune disorders (2023, May 25) retrieved 24 June 2024 from https://medicalxpress.com/news/2023-05-diabetes-drug-autoimmune-disorders.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Researchers identify potential new strategy to prevent side effects from immunotherapy

15 shares

Feedback to editors