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Sleep apnea link to cognitive decline raises need for targeted treatment options, says study

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Flinders University experts are working on better solutions for sleep apnea to ward off a range of health risks, including cognitive decline.

Improved solutions for (OSA), insomnia and other are being developed by the Flinders Sleep Health experts to reduce the associated negative health effects such as cardiovascular harm, diabetes, anxiety and depression and even long-term .

Heightened risk of cognitive function decline from undiagnosed OSA—particularly in living in the community—is the focus of one of the latest studies published in Sleep Health.

The study recorded the of more than 470 men aged from 41-87 years along side their daytime cognitive function for processing speed, visual attention, episodic memory recollection and other markers.

Measuring distinct features of brain during non-REM sleep, called 'sleep spindles', the study aimed to explore if these features can serve as markers of cognitive function.

"Non-REM sleep includes light stage 1 and 2 sleep, as well as deeper stage 3 sleep which is thought to play an important role in learning and memory," says Flinders University sleep researcher Dr. Jesse Parker.

"Our study found cross-sectional associations between various domains of next-day cognitive function and several sleep spindle metrics during stage 2 and stage 3 of their sleep cycle. The presence and severity of OSA was an important factor in this relationship."

While standard clinical tests for OSA may detect and help to improve this common sleep-related breathing disorder with interventions such as (CPAP) or specific dental devices, the condition does vary between people depending on gender, age and other factors.

Based on this latest Florey Adelaide Male Ageing Study results, the Flinders Health and Medical Research Institute Sleep Health researchers recommend long-term investigations into sleep spindle phases and OSA to improve future treatments—and to determine whether OSA interventions such as CPAP do improve sleep quality and cognitive function.

Sleep apnea affects more than 1 billion people globally and if untreated or severe may increase the risk of dementia and Parkinson's disease, hypertension, cardiovascular disease, anxiety and depression, reduced quality of life, traffic accidents and all-cause mortality, previous research has found. In Australia alone, the economic cost associated with including sleep disorders has been estimated at $66 billion a year.

"Poor sleep as a result of OSA, as well as delayed sleep and body clock disruption, may lead to chronic health conditions, including cognitive impairment, poor mental health and cardiovascular disease," says Associate Professor Andrew Vakulin, senior author on the publication and Flinders Health and Medical Research Institute (FHMRI) Sleep Health researcher.

"Highlighting the need for better treatments, our latest studies not only make more links between sleep disorders and poor health outcomes but also the need for tailored specific treatments for individual cases, including co-occurring conditions such as insomnia and ."

"Along with uncontrolled hypertension, this latest study also clearly links cognitive function to sleep in adult males, possibly made worse by undiagnosed moderate to severe OSA," says Associate Professor Vakulin.

More information: Jesse L. Parker et al, The association between sleep spindles and cognitive function in middle-aged and older men from a community-based cohort study, Sleep Health (2023). DOI: 10.1016/j.sleh.2023.03.007

Jesse L Parker et al, Associations of Baseline Sleep Microarchitecture with Cognitive Function After 8 Years in Middle-Aged and Older Men from a Community-Based Cohort Study, Nature and Science of Sleep (2023). DOI: 10.2147/NSS.S401655

Citation: Sleep apnea link to cognitive decline raises need for targeted treatment options, says study (2023, June 8) retrieved 24 June 2024 from
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