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Long COVID can impact fatigue and quality of life worse than some cancers, finds new study

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Fatigue is the symptom that most significantly impacts the daily lives of long COVID patients, and can affect quality of life more than some cancers, finds a new study led by researchers at UCL and the University of Exeter.

The research, published in BMJ Open , examines the impact of long COVID on the lives of over 3,750 who were referred to a long COVID clinic and used a digital app as part of their NHS treatment for the condition.

Patients were asked to complete questionnaires on the app about how long COVID was affecting them—considering the impact of long COVID on their day-to-day activities, levels of fatigue, depression, anxiety, breathlessness, brain fog, and their .

The researchers found that many long COVID patients were seriously ill and on average had fatigue scores worse or similar to people with cancer-related anemia or severe kidney disease. Their health-related quality of life scores were also lower than those of people with advanced metastatic cancers, like stage IV lung cancer.

Overall, the team found that the impact of long COVID on the daily activities of patients was worse than that of and was comparable to that of patients with Parkinson's disease.

Dr. Henry Goodfellow, who co-led the study alongside the late Professor Elizabeth Murray (both UCL Institute of Epidemiology & Health), said, "Up to around 17% of people who get COVID go on to develop long COVID. However, the impact of the condition on patients' day-to-day lives isn't fully understood."

"Our results have found that long COVID can have a devastating effect on the lives of patients—with fatigue having the biggest impact on everything from to work, chores and maintaining close relationships."

Not only does long COVID negatively impact the lives of patients on an individual level, the researchers also believe that it could have a significant economic and on the country.

In order to be referred to a long COVID clinic, a patient must have had symptoms in keeping with long COVID for at least 12 weeks after an acute infection.

Over 90% of long COVID patients using the app were of working age (18-65) and 51% said they had been unable to work for at least one day in the previous month, with 20% unable to work at all.

Meanwhile, 71% of patients were female. As working-age women make up a majority of the health and social care workforce, the impact of long COVID on their ability to function may add additional pressures to already stretched services.

Dr. Goodfellow said, "We hope that a greater understanding of the symptoms and impact of long COVID in these patients will help the NHS and policymakers to target by adapting existing services and designing new ones to better meet the needs of patients with long COVID."

According to the Office for National Statistics, around 1.4 million people in the UK had symptoms of long COVID as of July 2022. Alongside fatigue, patients typically experience breathlessness, anxiety, depression and brain fog.

However, this is the first study to report on the impact of the condition on day-to-day functioning and health-related quality of life in patients who have been referred for specialist rehabilitation in long COVID clinics across England.

Dr. Goodfellow said, "Our findings show that fatigue should be an important focus for clinical care and the design of rehabilitation services."

"Post-COVID assessment services should consider focusing on assessing and treating fatigue to maximize the recovery and return to work for sufferers of long COVID."

Co-author Professor William Henley, of the University of Exeter Medical School, said, "Long COVID is an invisible condition, and many people are left trying to manage significant changes to how they can function. Shockingly, our research has revealed that long COVID can leave people with worse and quality of life than some cancers, yet the support and understanding is not at the same level. We urgently need more research to enable the development of evidence-based services to support people trying to manage this debilitating new condition."

More information: Henry Goodfellow et al, The impact of fatigue as the primary determinant of functional limitations amongst patients with Post-COVID syndrome: a cross-sectional observational study, BMJ Open (2023). DOI: 10.1136/bmjopen-2022-069217

Journal information: BMJ Open

Citation: Long COVID can impact fatigue and quality of life worse than some cancers, finds new study (2023, June 7) retrieved 25 September 2023 from
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