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Study finds dopamine regulates how quickly and accurately decisions are made

Dopamine regulates how quickly and accurately decisions are made
Behavioral data. Response time (RT) distributions (n = 31, within-subject design) under Placebo (a), L-dopa (b), and Haloperidol (c). Choices of the suboptimal (20% reinforced) options in (ac) are coded as negative RTs, whereas choices of the optimal (80% reinforced) options are coded as positive RTs. d Accuracy per drug condition (chance level is 0.5). e Total rewards earned per condition. f Median RT per drug condition. Pl – Placebo, L – L-dopa, H – Haloperidol. For boxplots, lines represent the median, the box covers the upper and lower quartiles, and the whiskers denote the range of datapoints falling within 1.5 times the interquartile range. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-41130-y

A recent study provides new insight into the relationship between the release of the neurotransmitter dopamine and decision-making processes. The scientists found that when dopamine is released, decisions are made faster, but tend to be more inaccurate.

Researchers from the University of Cologne, the University Medical Center Hamburg-Eppendorf, TUD Dresden University of Technology and the Integrated Psychiatry in Winterthur (Switzerland) contributed to the study. The study "Dopamine regulates decision thresholds in human reinforcement learning in males" was published in the journal Nature Communications.

Dopamine is associated with a number of aspects of reward learning and action selection. The neurotransmitter also plays a role in various mental disorders and is important for one's own motivation. According to one theory, regulates how much effort is spent on actions, or how quickly they are performed.

Researchers investigated this in a new study using a learning task. They observed 31 male volunteers who learnt to associate abstract symbols with rewards. All participants performed different variants of the learning task under different drug conditions. In one condition, the release of dopamine was pharmacologically increased by L-dopa, a precursor of dopamine. In another condition, dopamine release was increased using a low dose of the medication Haloperidol. In the control condition, participants received a placebo.

Using novel computer models, the involved learning and decision-making processes were analyzed based on the distributions of the participants' .

In addition to its well-known functions, dopamine also seems to regulate a speed-accuracy trade-off. This describes the complex relation between a person's willingness to react slowly and make relatively fewer mistakes, and their willingness to react quickly and make relatively more mistakes.

The scientists were able to show that when dopamine release was elevated pharmacologically, the parameter that represents this speed-accuracy trade-off was reduced under both L-dopa and Haloperidol. This effect was stronger the faster the participants made decisions. The results therefore also show that computer models can provide improved insight into the function of certain neurotransmitter systems.

"These findings link two previously rather distinct theories on the role of dopamine," said Professor Dr. Jan Peters, Professor of Biological Psychology of the University of Cologne, who contributed to the study. "Dopamine controls motor response, but it can also regulate effort. Our data show a mechanism that could link these two aspects by shifting the speed-accuracy trade-off in favor of speed."

However, it is still unclear to what extent this mechanism also plays a role in decisions that are not directly about rewards, and what role motor functions plays in this. This is to be investigated in further studies.

More information: Karima Chakroun et al, Dopamine regulates decision thresholds in human reinforcement learning in males, Nature Communications (2023). DOI: 10.1038/s41467-023-41130-y

Journal information: Nature Communications

Citation: Study finds dopamine regulates how quickly and accurately decisions are made (2023, September 19) retrieved 28 September 2023 from
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