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Platelet biomarkers shed light on potential risk factors for sudden infant death syndrome

Platelet biomarkers shed light on potential risk factors for sudden infant death syndrome (SIDS)
Credit: Scientific Reports (2024). DOI: 10.1038/s41598-024-61949-9

In a new study, researchers examined whether blood platelets, which have serotonin (5-HT) and 14–3–3 signaling pathways similar to brain neurons, are abnormal in sudden infant death syndrome (SIDS). About 40% of SIDS cases have abnormalities in serotonin and 14–3–3 pathways in brainstem areas related to hypoxia, gasping, and arousal. Whether platelets, which have similar serotonin and 14–3–3 pathways, are also abnormal in SIDS is unknown.

In this study, researchers found platelets in postmortem blood from SIDS cases had significantly higher plasma and intra-platelet and lower intra-platelet 14–3–3 zeta and platelet surface glycoprotein IX (which is indirectly linked to 14–3–3) than controls. The research is published in the journal Scientific Reports.

The presence in SIDS of both platelet and brainstem serotonin and 14–3–3 suggest global dysregulation of these pathways. Platelet and plasma biomarkers may aid in the forensic determination of SIDS and have the potential to be predictive of SIDS risk in living infants.

Researchers, who previously found abnormalities in serotonin and protein 14–3–3 in the brains of infants dying from (SIDS), have now found that these abnormalities can be identified in SIDS platelets (small cells that circulate in blood).

Their work raises the possibility that future tests based on these platelet biomarkers may aid in discriminating SIDS from other causes of infant death or indicate risk for SIDS in living infants.

More information: Andrew L. Frelinger et al, Dysregulation of platelet serotonin, 14–3–3, and GPIX in sudden infant death syndrome, Scientific Reports (2024). DOI: 10.1038/s41598-024-61949-9

Journal information: Scientific Reports
Citation: Platelet biomarkers shed light on potential risk factors for sudden infant death syndrome (2024, May 20) retrieved 16 June 2024 from https://medicalxpress.com/news/2024-05-platelet-biomarkers-potential-factors-sudden.html
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