This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

peer-reviewed publication

trusted source

proofread

Study results indicate that pitavastatin inhibits interleukin-33 to suppress skin and pancreatic cancers

Cancer
Credit: Unsplash/CC0 Public Domain

A new study led by investigators from Mass General Cancer Center reveals that statins—commonly used cholesterol-lowering drugs—may block a particular pathway involved in the development of cancer that results from chronic inflammation. The findings are published in Nature Communications.

"Chronic inflammation is a major cause of cancer worldwide," said senior author Shawn Demehri, MD, Ph.D., a principal investigator at the Center for Cancer Immunology and Cutaneous Biology Research Center of Massachusetts General Hospital and an associate professor of Dermatology at Harvard Medical School.

"We investigated the mechanism by which drive the initiation of cancer-prone chronic inflammation in the skin and pancreas," says Demehri, who is also the Bob and Rita Davis Family MGH Research Scholar 2023-2028. "Furthermore, we examined safe and effective therapies to block this pathway in order to suppress chronic inflammation and its cancer aftermath."

Demehri and his colleagues' study relied on , animal models, human tissue samples and epidemiological data. The group's cell-based experiments demonstrated that environmental toxins (such as exposure to allergens and chemical irritants) activate two connected signaling pathways called the TLR3/4 and TBK1-IRF3 pathways. This activation leads to the production of the interleukin-33 (IL-33) protein, which stimulates inflammation in the skin and pancreas that can contribute to the development of cancer.

When they screened a library of U.S. Food and Drug Administration–approved drugs, the researchers found that a statin, pitavastatin, effectively suppresses IL-33 expression by blocking the activation of the TBK1-IRF3 signaling pathway. In mice, pitavastatin suppressed environmentally-induced inflammation in the skin and the pancreas and prevented the development of inflammation-related pancreatic cancers.

In human pancreas tissue samples, IL-33 was over-expressed in samples from patients with (inflammation) and compared with normal pancreatic tissue. Also, in analyses of electronic health records data on more than 200 million people across North America and Europe, use of pitavastatin was linked to a significantly reduced risk of chronic pancreatitis and pancreatic cancer.

The findings demonstrate that blocking IL-33 production with pitavastatin may be a safe and effective preventive strategy to suppress chronic inflammation and the subsequent development of certain cancers.

"Next, we aim to further examine the impact of statins in preventing cancer development in chronic inflammation in the liver and and to identify other novel, therapeutic approaches to suppress cancer-prone ," said Demehri.

More information: Park JH et al. Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression, Nature Communications (2024). DOI: 10.1038/s41467-024-48441-8

Journal information: Nature Communications
Citation: Study results indicate that pitavastatin inhibits interleukin-33 to suppress skin and pancreatic cancers (2024, May 30) retrieved 21 June 2024 from https://medicalxpress.com/news/2024-05-results-pitavastatin-inhibits-interleukin-suppress.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

New insights on how inflammatory molecule contributes to skin and pancreatic cancers

57 shares

Feedback to editors