Broad Institute of MIT and Harvard

Oncology & Cancer

What makes some immune cells better at killing melanoma

T cells rely on surface proteins called T cell receptors (TCRs) to bind to and destroy viruses, cancer cells, and other invaders in the body. T cells that infiltrate tumors, however, can have varied, sometimes ineffective ...

Genetics

Large genomic analysis highlights COVID-19 risk factors

In March of 2020, thousands of scientists around the world united to answer a pressing and complex question: what genetic factors influence why some COVID-19 patients develop severe, life-threatening disease requiring hospitalization, ...

Diseases, Conditions, Syndromes

Study of severe COVID-19 helps uncover the roots of sepsis

Sepsis is a dreaded, life-threatening condition that can occur when an infection spins out of control. Like a tsunami after an earthquake, sepsis occurs when an infection triggers a dysregulation of the immune system, which ...

Oncology & Cancer

Tumors hide from the immune system with help from this protein

Cancer drugs called immune checkpoint inhibitors boost the immune system's ability to find and destroy tumor cells, but they don't work for most patients. Researchers at the Broad Institute of MIT and Harvard, Massachusetts ...

Diseases, Conditions, Syndromes

How B cells fight the COVID-19 virus

A study of antibody-producing B cells from patients who recovered from COVID-19 reveals a new cross-reactive antibody and what makes some B cells more effective at neutralizing the virus.

Oncology & Cancer

New maps link thousands of genetic variants to disease genes

Genome-wide association studies (GWAS) have identified thousands of genetic variants that are associated with a wide range of diseases. But these studies often fall short of establishing what a genetic variant does to bring ...

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