By analyzing millions of small genetic differences across a person's genome, researchers can calculate a polygenic risk score to estimate someone's lifetime odds of developing a certain disease. Over the past decade, scientists ...
Feb 19, 2024
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The diabetes field has long classified the disorder into genetically distinct groups, including type 1 and type 2. However, new genetics research focused on a form of type 2 diabetes (T2D) that is becoming more common in ...
Feb 19, 2024
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While combing through the human genome in 2007, computational geneticist Pardis Sabeti made a discovery that would transform her research career. As a then-postdoctoral fellow at the Broad Institute of MIT and Harvard, Sabeti ...
Feb 8, 2024
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A team of scientists at the Broad Institute of MIT and Harvard has generated one of the first comprehensive maps of cell types in a mammalian brain using recently developed technology called spatial transcriptomics, which ...
Dec 13, 2023
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The immune system can carry out many biological processes, from killing viruses to fighting cancer, thanks in large part to approximately 100 key cell-signaling proteins called cytokines, which instruct immune cells what ...
Dec 7, 2023
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Cancer immunotherapy drugs called PD-1 inhibitors are widely used to stimulate the immune system to fight cancer, but many patients either don't respond or develop resistance to them. A new small-molecule drug candidate being ...
Oct 4, 2023
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Most Alzheimer's disease research on human brain tissue has studied postmortem samples, making it difficult for scientists to discern the earliest events in the brain that might have triggered the buildup of plaques and the ...
Sep 29, 2023
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Scientists using machine learning tools to analyze biomedical data often turn to neural network algorithms, but before these models became popular, another simpler type of machine learning algorithm called kernel methods ...
Sep 11, 2023
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Researchers have identified common and rare gene mutations that increase risk for schizophrenia. Yet it's unclear what biological mechanisms go awry in the brain to cause psychosis and other disabling symptoms, due in part ...
Sep 1, 2023
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Over the past decade, researchers have been developing polygenic scores—calculations of a person's likelihood of getting a disease based on the millions of small genetic differences across their genome. The accuracy of ...
Jul 7, 2023
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