Buck Institute for Research on Aging

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Medical research

Cellular senescence is associated with age-related blood clots

Cells that become senescent irrevocably stop dividing under stress, spewing out a mix of inflammatory proteins that lead to chronic inflammation as more and more of the cells accumulate over time. Publishing in the September ...

Neuroscience

Intervening in glial cells protects neurons in Parkinson's model

Loss of dopaminergic neurons is a hallmark of Parkinson's disease pathology. When dopaminergic neurons are stressed, they send out a call for help to nearby glial cells that are tasked with providing neuronal support, protection ...

Medical research

MANF identified as a rejuvenating factor in parabiosis

Older mice who are surgically joined with young mice in order to share a common bloodstream get stronger and healthier, making parabiosis one of the hottest topics in age research. Publishing in Nature Metabolism, researchers ...

Medical research

Does dietary restriction protect against age-related leaky gut?

Flies eating a Spartan diet are protected from leaky gut and the systemic inflammation associated with it as they age. Conversely, flies on a rich Atkins-like diet are more prone to developing intestinal permeability, a condition ...

Parkinson's & Movement disorders

A new therapeutic avenue for Parkinson's disease

Systemic clearing of senescent astrocytes prevents Parkinson's neuropathology and associated symptoms in a mouse model of sporadic disease, the type implicated in 95% of human cases. Publishing in Cell Reports, researchers ...

Medical research

Inhibiting TOR boosts regenerative potential of adult tissues

Adult stem cells replenish dying cells and regenerate damaged tissues throughout our lifetime. We lose many of those stem cells, along with their regenerative capacity, as we age. Working in flies and mice, researchers at ...

Medical research

Ketogenic diet improves healthspan and memory in aging mice

A ketogenic diet significantly improved memory in aging mice and increased the animal's chances of surviving to old age. Results of the study from Eric Verdin's lab at the Buck Institute for Research on Aging in Novato, CA ...

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