California Institute of Technology

Genetics

Mapping bacterial neighborhoods in the gut

The microscopic populations of bacteria in our intestines are, in some ways, just like us: They live in communities, eat, work, reproduce, and eventually die. Many of these bacterial species live in harmony with our bodies, ...

Neuroscience

Biomarker for Parkinson's disease may originate in the gut

Parkinson's disease (PD) is a debilitating neurodegenerative disorder, impairing the motor functions of millions of elderly people worldwide. Often, people with PD will experience disturbances in gastrointestinal function, ...

Immunology

Poop matters: Making the mouse gut microbiome more human-like

There is a growing consensus that the gut microbiome is involved in many aspects of physical and mental health, including the onset of Parkinson's disease, multiple sclerosis, and even some behaviors. The microbiota of the ...

Neuroscience

Protein signposts guide formation of neural connections

The brain's complex tangle of interconnected nerve cells processes visual images, recalls memories, controls motor function, and coordinates countless other functions. A major goal of neuroscience is understanding how the ...

Medical research

Scientists identify a genetic basis for healthy sleep

From organisms as simple as worms to those as complex as humans, sleep is a fundamental necessity. But although an estimated 50 to 70 million people in the United States suffer from a chronic sleep disorder, the genetic mechanisms ...

Cardiology

Mending broken hearts with neural crest cells

Zebrafish—striped fish a few centimeters long—have the ability to regrow up to 20 percent of their hearts after sustaining major damage. Now, Caltech scientists have discovered that embryonic cells from the hindbrain, ...

Medical research

New polymer heart valve implanted in first patient

Caltech researchers have helped to design a new generation of heart valves that are longer-lasting, cost less to manufacture, and are more biocompatible than options that are currently available to patients. As part of an ...

Neuroscience

How memories form and fade

Why is it that you can remember the name of your childhood best friend that you haven't seen in years yet easily forget the name of a person you just met a moment ago? In other words, why are some memories stable over decades, ...

Neuroscience

Settling the debate on serotonin's role in sleep

Serotonin is a multipurpose molecule found throughout the brain, playing a role in memory, cognition, and feelings of happiness and other emotions. In particular, researchers have long debated serotonin's role in sleep: Does ...

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