Cincinnati Children's Hospital Medical Center

Medications

Scientists discover key regulator of neuron function and survival

Scientists studying neuronal energy metabolism found evidence that the loss of an important energy regulator called AMPK in neural stem cells or glial cells called astrocytes causes neuronal death in laboratory rodents. They ...

Medical research

Two discoveries boost next-generation organoid development

In back-to-back reports published Aug. 27, 2020, in Nature Communications, a team of scientists from Cincinnati Children's and Japan report discoveries that will be vital to a new wave of more-complex organoid development.

Obstetrics & gynaecology

Immune system works differently between first and later pregnancies

Among the holy quests of serious and mysterious medical challenges that doctors and research scientists strive to vanquish is preventing miscarriages, stillbirth and other pregnancy complications including preterm births.

Immunology

How a fat cell's immune response makes obesity worse

When obesity occurs, a person's own fat cells can set off a complex inflammatory chain reaction that can further disrupt metabolism and weaken immune response—potentially placing people at higher risk of poor outcomes from ...

Genetics

Finding genetic ripple effects in a single-cell environment

Although advances in genetics and genomics reveal numerous disease-associated gene mutations associated with disease, physicians and researchers still wrestle with the tricky challenge of linking those mutations to actual ...

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