Cold Spring Harbor Laboratory

Diseases, Conditions, Syndromes

How a bad day at work led to better COVID predictions

Talking about your bad day at work could lead to great solutions. Cold Spring Harbor Laboratory (CSHL) Associate Professor Saket Navlakha and his wife, Dr. Sejal Morjaria, an infectious disease physician at Memorial Sloan ...

Neuroscience

Reversing a genetic cause of poor stress responses in mice

Everyone faces stress occasionally, whether in school, at work, or during a global pandemic. However, some cannot cope as well as others. In a few cases, the cause is genetic. In humans, mutations in the OPHN1 gene cause ...

Medical research

Regulatory RNAs promote breast cancer metastasis

Cold Spring Harbor Laboratory (CSHL) scientists have discovered a gene-regulating snippet of RNA that may contribute to the spread of many breast cancers. In animal experiments, the researchers could reduce the growth of ...

Medications

Calibrating kidney function for cancer patients

Cold Spring Harbor Laboratory (CSHL) scientists have developed a new model for assessing kidney function in cancer patients as part of an international collaboration that involved contributions from the United Kingdom and ...

Neuroscience

How does the brain process fear?

When a frightful creature startles you, your brain may activate its fear-processing circuitry, sending your heart racing to help you escape the threat. It's also the job of the brain's fear-processing circuits to help you ...

Oncology & Cancer

Giving the immune system a double boost against cancer

Cancer immunotherapies, which empower patients' immune systems to eliminate tumors, are revolutionizing cancer treatment. Many patients respond well to these treatments, sometimes experiencing long-lasting remissions. But ...

Medical research

Reward and punishment take similar paths in the mouse brain

Cold Spring Harbor Laboratory (CSHL) scientists have discovered neurons in the mouse brain that help an animal learn to avoid negative experiences. The cells reside in a part of the brain involved in regulating the motivations ...

Neuroscience

Immune cells sculpt circuits in the brain

Immune cells play an unexpected role in fine-tuning the brain's neural circuits, according to research published in September, 2020 in Neuron. The immune cells that reside there, known as microglia, not only protect the brain ...

Neuroscience

The neurons that connect stress, insomnia, and the immune system

Scientists at Cold Spring Harbor Laboratory (CSHL) and Stanford University have pinpointed the circuit in the brain that is responsible for sleepless nights in times of stress—and it turns out that circuit does more than ...

Medical research

Understanding the inner workings of the human heart

Researchers have investigated the function of a complex mesh of muscle fibers that line the inner surface of the heart. The study, published in the journal Nature, sheds light on questions asked by Leonardo da Vinci 500 years ...

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