Federation of American Societies for Experimental Biology

Arthritis & Rheumatism

New psoriatric arthritis mouse model developed

Psoriatic arthritis (PsA) is a chronic inflammatory disease that can reduce mobility and agility in patients. PsA is known to increase the risk of type II diabetes. A recent study published in The FASEB Journal tested a novel ...

Oncology & Cancer

Alternative molecular mechanisms observed in cancer cells

Current anti-cancer drugs can be quite effective but too often, tumors are not fought off completely and end up returning. A recent study published in The FASEB Journal provides the first evidence that some cancer cells evade ...

Genetics

DNA repair gene linked to male infertility

A key DNA repair gene known as X-ray repair cross-complementing group 1, or XRCC1, plays a vital role in maintaining genomic stability and is highly expressed in the early stages of sperm cell development (also known as spermatogenesis). ...

Oncology & Cancer

New strategy to reduce cancer drug's cardiotoxic effects

Doxorubicin (Doxo) is a widely used chemotherapeutic drug for cancer, though it can have toxic effects on the heart. A recent animal study published in The FASEB Journal investigated whether the cardioregulatory protein chromogranin ...

Cardiology

Study suggests novel biomarker for predicting AFib progression

A human study published in The FASEB Journal suggests a novel type of biomarker to predict the progression of atrial fibrillation (AF), the most common form of irregular heart rhythm. Despite inconsistent evidence to date, ...

Neuroscience

GI neuroimmune disruption contributes to Gulf War Illness

Many Persian Gulf War veterans experience Gulf War Illness (GWI), a chronic condition with symptoms ranging from gastrointestinal to neurological. While exposure to the anti-nerve gas pyridostigmine bromide (PB) is linked ...

Medical research

Magnetic fields enhance bone remodeling

Since the creation of 3-D-printed (3DP) porous titanium scaffolds in 2016, the scientific community has been exploring ways to improve their ability to stimulate osteogenesis, or bone remodeling. A recent study published ...

Oncology & Cancer

Molecular mechanisms behind AICAr drug; impact on ALL

AICAr (5-amino-4-imidazolecarboxamide riboside, also called Acadesine) has been found to inhibit cell proliferation and has cytotoxic potential for childhood acute lymphoblastic leukemia (ALL) cells. Much of the drug's cytotoxic ...

Obstetrics & gynaecology

Alternations in gut microbiota in pregnancy and lactation

Recent studies have shown that maternal gut microbiota in humans primes the offspring's immune and metabolic development during pregnancy and lactation. Due to environmental factors that are impractical to control in human ...

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