Friedrich Miescher Institute for Biomedical Research

Genetics

Epigenetic regulation of face formation

Each face is unique, even though the genes controlling facial shape are almost identical in every individual. Filippo Rijli and his team at the Friedrich Miescher Institute for Biomedical Research (FMI) have discovered an ...

Neuroscience

Transcriptional control of sound discrimination

Filippo Rijli and his team at the Friedrich Miescher Institute for Biomedical Research have identified two genes that control sound discrimination in the brain. The Hox2 transcription factors act in the mouse brain stem and ...

Neuroscience

Deviations from expectations: detecting moving objects

Pawel Zmarz and Georg Keller at the FMI have identified neurons in the visual cortex that enable the detection of moving objects as we move along. These neurons integrate visual and motor-related input and signal a mismatch ...

Genetics

Controlling cell-fate decisions

Rafal Ciosk and his group at the FMI have identified an important link between the Notch signaling pathway and PRC2-mediated gene silencing. They showed that a fine balance between epigenetic silencing and signaling is crucial ...

Neuroscience

What you see is not always what you get

Georg Keller and his group at the Friedrich Miescher Institute for Biomedical Research (FMI) have identified neurons in the visual cortex whose activity predicts an upcoming visual stimulus. This activity emerges with experience ...

Oncology & Cancer

Aggressiveness of acute myeloid leukemia elucidated

Antoine Peters and colleagues at the Basel University Children's Hospital (UKBB) have discovered why acute leukemias with the same genetic abnormality vary in their aggressiveness based on their cellular origin. They found ...

Neuroscience

How fear makes us freeze

Andreas Lüthi and his group at the Friedrich Miescher Institute for Biomedical Research (FMI) have identified and characterized the neuronal circuitry in the brain, which controls defensive behavior in threatening situations. ...

Neuroscience

Unraveling complex neuronal networks

One of the fundamental questions in neuroscience is how neuronal circuits are wired to process information. The research group led by Rainer Friedrich has developed new methods to determine the complex morphology of densely ...

Medical research

Targeting cancer proteins for degradation

Cancer research is increasingly focusing on therapeutic approaches in which disease causing proteins are marked for early degradation. Nicolas Thomä and his group at the Friedrich Miescher Institute for Biomedical Research ...

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