Friedrich Miescher Institute for Biomedical Research

Neuroscience

Interneuron plasticity ensuring long-term memory formation

Understanding learning and memory processes is of fundamental importance to the study of brain function and provides valuable insights for disorders where these processes are disturbed. The current study of Pico Caroni from ...

Neuroscience

Defect in retinal computation linked to congenital nystagmus

Botond Roska and his group at the Friedrich Miescher Institute for Biomedical Research (FMI) implicate a clearly defined neuron type and its circuit in the retina in the pathophysiology of idiopathic congenital nystagmus. ...

Neuroscience

Mapping face sensation in the brainstem

Filippo Rijli and his group at the FMI have shown how the formation of a sensory topographic map in the brainstem is controlled by a single transcription factor, thus shedding light on a decades-old question in neuroscience. ...

Neuroscience

Controlling anxiety

Researchers at Andreas Lüthi's laboratory have identified a cell type in the brain, which controls anxiety - a complex behavioral state - and have elucidated the underlying mechanisms. These findings thus improve our understanding ...

Neuroscience

Giant proteins determine properties of neurons

Giant membrane-associated proteins called ankyrins extend into the cytoplasm to arrange and stabilize microtubules in axons and synapses. This determines not only the diameter and hence the functional properties of axons, ...

Genetics

Genetic guides to epigenetics

Dirk Schübeler and his group at the Friedrich Miescher Institute for Biomedical Research (FMI) identify determinants that set epigenetic marks along the genome. The new study, published in Nature, shows that genetic activity ...

Neuroscience

New function for rods in daylight

(Medical Xpress)—Vision – so crucial to human health and well-being – depends on job-sharing by just a few cell types, the rod cells and cone cells, in our retina. Botond Roska and his group have identified a novel ...

Oncology & Cancer

Stopping anti-CCL2 breast cancer treatment aggravates the disease

Mohamed Bentires-Alj and his team at the Friedrich Miescher Institute for Biomedical Research (FMI) together with scientists from the Novartis Institutes for BioMedical Research (NIBR) show in a study published today in Nature ...

Medical research

Mechanism of action of thalidomide elucidated

(Medical Xpress)—Scientists led by Nicolas Thomä at the Friedrich Miescher Institute for Biomedical Research have clarified the workings of thalidomide at the molecular level. Their analysis of various structures, published ...

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