German Cancer Research Center

The German Cancer Research Center (known as the Deutsches Krebsforschungszentrum or simply DKFZ in German), is a national cancer research center based in Heidelberg, Germany. It is a member of the Helmholtz Association of German Research Centres, the largest scientific organization in Germany.

Website
http://www.dkfz.de/en/index.html
Wikipedia
https://en.wikipedia.org/wiki/German_Cancer_Research_Center

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Immunology

The wrong track: How papillomaviruses trick the immune system

Specific antibodies protect us against viral infections—or do they? Researchers at the German Cancer Research Center (DKFZ) studied the immune response to papillomaviruses in mice and discovered a hitherto unknown mechanism ...

Oncology & Cancer

CAR T cell therapy: Potential for considerable savings

Chimeric antigen receptor (CAR) T cell therapy is a new and in some cases highly effective form of immunotherapy to treat certain types of cancer of the blood and lymph system. This promising treatment comes at a cost, however: ...

Medical research

Muscles support a strong immune system

In the fight against cancer or chronic infections, the immune system must be active over long periods of time. However, in the long run, the immune defense system often becomes exhausted. Scientists at the German Cancer Research ...

Medical research

Preventing metastasis: An antibody with therapeutic potential

A receptor in the cell layer that lines the blood vessels from the inside stimulates both the formation of new blood vessels in tumors and metastasis. Scientists at the German Cancer Research Center in Heidelberg (DKFZ) and ...

Genetics

Intestinal microbes reprogram genetic activity of gut mucosa

Scientists from the German Cancer Research Center and the Hebrew University in Jerusalem demonstrated in mice that intestinal bacteria reprogram DNA activity in cells of the gut mucosa and thus have a considerable impact ...

Medical research

Traces of immortality in tumor DNA

To gain an infinite lifespan, cancer cells need to maintain the ends of their chromosomes, known as telomeres. They achieve this in various ways. Scientists from the German Cancer Research Center systematically investigated ...

Immunology

How dying cells prevent dangerous immune reactions

Dying cells in the body can keep the immune system in check, thus preventing unwanted immune responses against the body's own tissues. Scientists from the German Cancer Research Center have now identified a receptor on murine ...

Medical research

Metabolic adaptation ensures survival of colon cancer cells

Colon cancer cells deficient in p53, one of the most important control proteins in cell growth, activate a particular metabolic pathway to adapt to the lack of oxygen and nutrients inside the tumor. Statins, which are often ...

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