The Gladstone Institutes is comprised of three institutes in the San Francisco area which began in 1979. The Gladstone Institute of Cardiovascular Disease focuses on atherosclerosis and its complications. The Gladstone Institute of Virology and Immunology focuses on the origins of HIV/AID and development of treatment and prevention. The Gladstone Institute of Neurological Disease focuses on Alzheimer's Disease and related aging factors. The Gladstone Institute is an independent center for research, however it is affiliated with the University of California, San Francisco. The Gladstone Institutes have entered into joint research ventures with Merck & Co. Inc to form the Center for Translational Research. The center's focus is to bring about rapid drug discoveries and to bridge the gap between traditional basic research and making available therapies to treat patient diseases.
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In recent years, scientists have used gene modification technologies to reprogram immune cells into therapeutics that can attack cancers. But such immunotherapies don't work for all patients or all cancer types, and screening ...
Sep 14, 2023
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Gamma delta T cells, a special type of cell in the immune system, are incredibly effective at recognizing and killing cancer cells. Cancer patients with higher levels of these T cells in their tumors tend to fare better than ...
Aug 30, 2023
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In patients with neurological diseases like Alzheimer's disease and multiple sclerosis, immune cells in the brain known as microglia that normally fulfill beneficial functions become harmful to neurons, leading to cognitive ...
Jun 8, 2023
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Researchers at Gladstone Institutes, the Broad Institute of MIT and Harvard, and Dana-Farber Cancer Institute have turned to artificial intelligence (AI) to help them understand how large networks of interconnected human ...
May 31, 2023
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The human brain has a sweet tooth, burning through nearly one quarter of the body's sugar energy, or glucose, each day. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) have shed new light on exactly how ...
Apr 20, 2023
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Compared to those of us who live at sea level, the 2 million people worldwide who live above 4,500 meters (or 14,764 feet) of elevation—about the height of Mount Rainier, Mount Whitney, and many Colorado and Alaska peaks—have ...
Mar 7, 2023
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Of all the known genetic risk factors for late-onset Alzheimer's disease, the strongest is a gene for the protein called ApoE4. People with one copy of this gene are 3.5 times more likely, on average, to develop Alzheimer's ...
Feb 21, 2023
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By the time you test positive for COVID-19, the SARS-CoV-2 virus has already taken up residence in your respiratory system. With each breath, you expel invisible viral particles into the air—a process known as viral shedding. ...
Sep 9, 2022
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For days, and even years, after someone suffers a stroke or traumatic brain injury, they have an increased risk of developing epilepsy. Now, researchers at Gladstone Institutes discovered that star-shaped cells called astrocytes ...
Jul 6, 2022
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When faced with a formidable foe for months on end, the immune system's T cells begin to tire. Whether fighting a cancer or a chronic infection, they become less effective over time, a phenomenon dubbed "T cell exhaustion" ...
Jun 28, 2022
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