Scientists at the Gladstone Institutes have discovered how the major genetic risk factor for Alzheimer's disease causes memory impairment. A specific type of brain activity important for memory replay is disrupted in mice ...
May 6, 2016
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107
Scientists at the Gladstone Institutes have deciphered how a protein called Arc regulates the activity of neurons—providing much-needed clues into the brain's ability to form long-lasting memories. These findings, reported ...
Jun 9, 2013
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Researchers from the Gladstone Institutes have shown for the first time that the protein BRCA1 is required for normal learning and memory and is depleted by Alzheimer's disease.
Nov 30, 2015
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315
In a major breakthrough, scientists at the Gladstone Institutes transformed skin cells into heart cells and brain cells using a combination of chemicals. All previous work on cellular reprogramming required adding external ...
Apr 28, 2016
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309
In the fight against HIV, microbicides—chemical compounds that can be applied topically to the female genital tract to protect against sexually transmitted infections—have been touted as an effective alternative to condoms. ...
Nov 12, 2014
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Scientists from the Gladstone Institutes and the University of Michigan have identified a cellular mechanism that can be targeted to treat ALS. The researchers revealed that increasing levels of a certain key protein successfully ...
Jun 8, 2015
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When faced with a formidable foe for months on end, the immune system's T cells begin to tire. Whether fighting a cancer or a chronic infection, they become less effective over time, a phenomenon dubbed "T cell exhaustion" ...
Jun 28, 2022
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275
When mice with atopic dermatitis—a common type of allergic skin inflammation—are treated with drugs that target the immune system, their thickened, itchy skin generally heals quickly. But scientists have now discovered ...
Mar 30, 2022
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173
Scientists at the Gladstone Institutes have discovered that an FDA-approved anti-epileptic drug reverses memory loss and alleviates other Alzheimer's-related impairments in an animal model of the disease.
Aug 6, 2012
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2
A stem cell is one with infinite possibilities. So, for decades, scientists have puzzled over how the cell chooses to keep being a stem cell and continue dividing, or specialize into a specific cell type, like a heart or ...
May 10, 2018
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