The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), situated on the Utrecht Science Park 'De Uithof'. Since 2008, the Hubrecht is affiliated with the UMC Utrecht.
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The Organoid group at the Hubrecht Institute has identified a new link between FBXW7 mutations and epidermal growth factor receptor (EGFR) signaling activity. The FBXW7 gene is commonly mutated in colorectal cancer and such ...
Mar 18, 2024
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The Organoid group at the Hubrecht Institute produced the first organoid model of the human conjunctiva. These organoids mimic the function of the actual human conjunctiva, a tissue involved in tear production. Using their ...
Jan 11, 2024
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The Organoid Group (Hubrecht Institute) and the Rare Cancers Genomics Team (IARC/WHO) found a way to grow samples of different types of neuroendocrine tumors (NETs) in the lab. While generating their new model, the researchers ...
Dec 11, 2023
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Researchers at the Hubrecht Institute have laid the foundation for the development of a gene therapy for the genetic heart disease arrhythmogenic cardiomyopathy (ACM). Their approach, based on replacement of the PKP2 gene, ...
Dec 7, 2023
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Cardiovascular diseases, such as heart attacks, are a leading cause of death worldwide resulting from a limited self-healing power of the heart. Unlike humans, zebrafish have the remarkable capacity to recover from cardiac ...
May 18, 2023
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Head and neck cancer (HNC) is an overarching term used for several types of cancer, including the most common form called head and neck squamous cell carcinoma (HNSCC). HNC patients can be treated with a combination of surgery, ...
May 12, 2023
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Mutations in genes that form the desmosome are the most common cause of the cardiac disease arrhythmogenic cardiomyopathy (ACM), which affects one in 2,000 to 5,000 people worldwide. Researchers from the group of Eva van ...
Mar 22, 2023
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Researchers from the group of Eva van Rooij in collaboration with the UMC Utrecht identified a new mutation that leads to the cardiac disease arrhythmogenic cardiomyopathy (ACM).
Mar 2, 2023
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Researchers from the Organoid group (former Clevers group, Hubrecht Institute) together with researchers from the Princess Máxima Center for pediatric oncology have established novel human organoid models of fatty liver ...
Feb 23, 2023
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Researchers from the Organoid group (formerly the Clevers group) have improved human small intestinal organoids—miniature versions of the small intestine. This will help them to better study the functioning of the small ...
Aug 23, 2022
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