Hypophosphatasia (HPP) is a rare congenital metabolic disorder. The frequency of severe courses of disease is estimated at 1:100 000: A deficiency of the enzyme phosphatase results in insufficient mineralization of the bones ...
Jan 27, 2020
0
4
Particularly in the case of accelerated drug approvals and drugs for rare diseases (orphan drugs), the evidence available at the time of market access is often insufficient for the early benefit assessment of drugs. Often, ...
Jan 24, 2020
0
1
In the summer of 2019, larotrectinib was approved as the first drug in Europe to be used in numerous different solid tumours if the tumour tissue displays a so-called NTRK gene fusion. Since such a fusion of a neurotrophic ...
Jan 16, 2020
0
1
How can the perspectives of patients with multiple sclerosis (MS) be given more consideration in clinical trials? This question was investigated and corresponding recommendations were developed by a working group of the Drug ...
Dec 18, 2019
0
1
Do patients with advanced heart failure benefit from data-supported, timely management in collaboration with a medical telemedical centre, in short: telemonitoring with defined minimum requirements?
Nov 4, 2019
0
2
In early July, the German Institute for Quality and Efficiency in Health Care (IQWiG) conducted two early benefit assessments to investigate whether certain drug combinations with pembrolizumab have advantages in comparison ...
Sep 20, 2019
0
0
Since its approval in April 2019, dacomitinib has been available for the first-line treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor ...
Aug 19, 2019
0
3
Patients with a history of coronary heart disease (CHD) or acute coronary syndrome (ACS) benefit more from treatment with a statin in combination with ezetimibe than from treatment with a statin alone. However, there is no ...
Aug 8, 2019
0
3
Does the treatment success of a certain procedure depend on the number of cases in a hospital or on how often the doctors working there have already performed this procedure? In Germany, this is the subject of 8 commissions ...
Jul 29, 2019
0
3
Glioblastoma is an aggressive brain tumor that usually occurs in late adulthood. Just two years after diagnosis, only 13.6 percent of patients are still alive. Standard treatment consists of surgery, followed by radiation ...
Jul 1, 2019
0
4
