Individuals with asthma and COPD are subject to debilitating bronchospasm as a result of airways that are hyperresponsive to stimuli. Factors that lead to the development of airway hyperresponsiveness are not well characterized.
Jan 9, 2014
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The effectiveness of toxin-neutralizing antibodies is considered to be mediated through the interaction of the variable region of the antibody and the toxin; however, recent studies suggest that the constant region (Fc) of ...
Jan 9, 2014
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Doxorubicin is a widely used as a component of chemotherapy regimes; however, the use of doxorubicin is associated with severe cardiotoxicity. It is unclear exactly how doxorubicin promotes cardiotoxicity, but it has been ...
Jan 2, 2014
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Currently, opioids are the standard treatment for chronic pain. Patients on opioids for long periods of time become desensitized to these drugs or become paradoxically hypersensitive to pain (hyperalgesia); however, the adaptive ...
Jan 2, 2014
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An unfortunate side effect of the platinum-chemotherapy drug oxaliplatin is the development of neurotoxicity, which can adversely affect a patient's quality of life; therefore, the benefit of oxaliplatin-based therapy must ...
Dec 20, 2013
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Patients with the connective tissue disorder Loeys-Dietz syndrome (LDS) are at high risk for aortic aneurysm. LDS results in the presence of missense mutations within either of the genes encoding receptors for TGF-β. LDS-associated ...
Dec 20, 2013
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Congenital aniridia is a progressive disease that is associated with improper development of eye structures as well as abnormalities in the brain and pancreas. A variety of nonsense mutations in the PAX6 gene are linked with ...
Dec 20, 2013
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The decreased vision loss that accompanies age-related macular degeneration (AMD) is associated with abnormal blood vessel growth in the eye. Frequencies of AMD development are different among racial backgrounds, with occurrence ...
Dec 20, 2013
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While there are well-established mouse models to identify cancer-causing agents, similar models are not available to readily test and identify age-promoting agents. Recently, a mouse strain (p16LUC mice) was developed that ...
Dec 16, 2013
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Dense deposit disease is a rare congenital disorder that is associated with complement dysfunction and often results in end stage renal disease within 10 years of the initial diagnosis. A small percentage of dense deposit ...
Dec 16, 2013
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