Journal of Clinical Investigation

Medical research

Leaky lymphatics lead to obesity in mice

Lymphatic vessels play multifaceted roles in the body, including the absorption of dietary lipid in the intestines as well as the movement of immune cells throughout the body. Previous work by Guillermo Oliver and colleagues ...

Cancer

Understanding the role of human polyomaviruses in cancer

Human polyomaviruses are commonly found in the population and generally do not produce noticeable symptoms. However, one type of human polyomavirus, the Merkel cell polyomavirus, is known to cause a rare form of skin cancer ...

Cancer

Innate immune landscape in glioblastoma patient tumors

Glioblastoma is an extremely aggressive brain tumor with limited treatment options. Recent progress in using immunotherapy-based treatment options in other tumor types has spurred interest in developing approaches that might ...

Diseases, Conditions, Syndromes

Kidney fibrosis in older transplants links to failure

Clinically, kidney fibrosis can be used to assess stage, progression, and prognosis for both kidney transplants and kidney disease. There is debate as to whether kidney fibrosis is a maladaptive, injury-triggered process ...

Diseases, Conditions, Syndromes

Identification of a driver of fibrosis in chronic kidney disease

Chronic kidney disease can develop in response to a variety of insults and is characterized by progressive renal fibrosis and atrophy of kidney tubule. Therapeutic options are limited and the disease is often not detected ...

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