Journal of Clinical Investigation

Inflammatory disorders

Alterations in fatty acid synthesis linked to sepsis inflammation

Sepsis is a leading cause of death for patients in intensive care units. The excessive systemic inflammation in individuals with sepsis damages organs and can lead to death. Therapeutic options for sepsis are limited and ...

Alzheimer's disease & dementia

Targeting inflammatory pathway reduces Alzheimer's disease in mice

Alzheimer's disease (AD) is the most common form of dementia and is characterized by the formation of β-amyloid plaques throughout the brain. Proteins known as chemokines regulate inflammation and the immune response. In ...

Cancer

A noncoding RNA promotes pediatric bone cancer

Ewing sarcoma is a cancer of bone or its surrounding soft tissue that primarily affects children and young adults. A hallmark of Ewing sarcoma is a translocation event that results in the fusion of an RNA binding protein, ...

page 6 from 23