Journal of Clinical Investigation

Cardiology

Understanding adverse blood vessel remodeling following stenting

Atherosclerosis is a leading cause of heart attacks and stroke. The narrowing of blood vessels that is caused by atherosclerosis can be treated with angioplasty or stenting to improve blood flow. However, the stenting process ...

Cancer

Tumor-associated neutrophils boost anti-tumor immune responses

Lung cancer is a leading cause of cancer-related deaths in both men and women, and survival depends on the stage of cancer at diagnosis. An inflammatory response is induced following tumor formation, and the immune cells ...

Immunology

Food allergy development linked to skin exposure

Food allergies are on the rise in the U.S. and other developed countries. In patients, food allergies appear as a variety of symptoms, ranging from mild skin inflammation to severe asthma. Recent studies suggest that contact ...

Diseases, Conditions, Syndromes

Dysfunctional ketogenesis promotes fatty liver disease in mice

Approximately 1 billion people worldwide have non-alcoholic fatty liver disease (NAFLD). Individuals with this disease have an increased risk of type 2 diabetes, obesity, and kidney disease. It is not clear how this disease ...

Medical research

Mouse model provides new insight in to preeclampsia

Worldwide, preeclampsia is a leading cause of maternal deaths and preterm births. This serious pregnancy complication results in extremely high blood pressure and organ damage. The onset of preeclampsia is associated with ...

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