Journal of Clinical Investigation

Cardiology

Identification of genetic risk factors for stroke

Stroke is one of the leading causes of death worldwide. While many lines of evidence suggest that stroke risk is heritable, only a small number of genes associated with stroke have been identified.

Cardiology

An autoimmune response may contribute to hypertension

High blood pressure is a major risk factor for heart attack, stroke, chronic heart failure, and kidney disease. Inflammation is thought to promote the development of high blood pressure, though it is not clear what triggers ...

Cancer

Mesothelial cells promote ovarian cancer metastasis

Less than half of the women diagnosed with ovarian cancer will survive beyond 5 years. Ovarian cancer readily spreads to abdominal organs, which are covered by a layer of cells called the mesothelium. Ovarian cancer cells ...

Medical research

Tumor blood vessel protein provides potential therapeutic target

Tumor blood vessels supply oxygen and nutrients to cancer cells and provide access to other organs. While tumor vasculature shares many features with normal vessels, their unique characteristics are potential therapeutic ...

HIV & AIDS

Individual genotype influences effectiveness of HIV vaccine

Almost 40 million people worldwide live with HIV/AIDS. Despite great effort, HIV-1 vaccine development has been challenging. A recent HIV vaccine trial, known as RV144, revealed that a combination of 2 vaccines protected ...

Diseases, Conditions, Syndromes

Improving lymphatic function protects mice from experimental colitis

Chronic inflammatory bowel disease can be painful and debilitating. Both genetics and environment are thought to promote disease, but it is not fully understood how chronic IBD develops. Emerging evidence indicates that IBD ...

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