Lung cancer is a leading cause of cancer-related deaths in both men and women, and survival depends on the stage of cancer at diagnosis. An inflammatory response is induced following tumor formation, and the immune cells ...
Nov 11, 2014
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Bone integrity requires skeletal remodeling, which involves both bone formation and resorption. It has been previously shown that the formation of new bone is triggered by degradation of older bone. However, it is unknown ...
Aug 1, 2013
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Glioblastoma is an extremely aggressive brain tumor with limited treatment options. Recent progress in using immunotherapy-based treatment options in other tumor types has spurred interest in developing approaches that might ...
Feb 25, 2016
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The immunosuppressive drug rapamycin has been shown to increase longevity in mice even when treatment begins at an advanced age. It is unclear if the extension of life also correlates with prolonged health and vigor.
Jul 25, 2013
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Although combinatorial antiretroviral therapies (cARTs) have dramatically reduced the occurrence of HIV-1-related dementia and encephalitis, recent studies have shown a rise in the number of HIV-positive individuals who will ...
May 9, 2016
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An arrest in cell proliferation, also referred to as cellular senescence, occurs as a natural result of aging and in response to cellular stress. Senescent cells accumulate with age and are associated with many aging phenotypes, ...
Nov 15, 2013
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Combination antiretroviral therapy has dramatically increased the life expectancy for HIV-infected patients. However, the prevalence of HIV-associated neurocognitive disorders, which may be triggered by inflammation in the ...
Sep 9, 2014
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Duchenne muscular dystrophy (DMD) is a degenerative skeletal muscle disease caused by mutations in the protein dystrophin. Dystrophin functions to protect muscle cells from injury and loss of functional dystrophin results ...
Apr 1, 2013
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Almost 40 million people worldwide live with HIV/AIDS, with an estimated 2.5 million new cases per year. Therefore, there has been a large global effort to develop an effective vaccine against the virus. HIV-1 vaccine development ...
Oct 1, 2014
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Type 2 diabetes (T2D) is the most common form of diabetes and is associated with many complications. T2D is preventable through weight control and exercise; however, many individuals are unaware that they are at risk and ...
Sep 16, 2013
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