Journal of Clinical Investigation

The Journal of Clinical Investigation is a monthly open access biomedical scientific journal, with a 2010 impact factor of 14.152. It was established in 1924. The editorial board is unusual in that its members are located chiefly at a single academic medical center and are predominantly members of the American Society for Clinical Investigation. Its leadership changes every five years: As of March 2007, it is located at the University of Pennsylvania and the current editor-in-chief is Laurence A. Turka (Harvard University). From March 2002 to March 2007, the board was located at Columbia University, with Andrew Marks as editor-in-chief.

Website
http://www.jci.org/
Wikipedia
http://en.wikipedia.org/wiki/Journal_of_Clinical_Investigation

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Immunology

Immune cells essential to establishing pregnancy

New research from the University of Adelaide shows for the first time that immune cells known as macrophages are critical to fertility by creating a healthy hormone environment in the uterus.

HIV & AIDS

'Redesigned' antibodies may control HIV

With the help of a computer program called "Rosetta," researchers at Vanderbilt University have "redesigned" an antibody that has increased potency and can neutralize more strains of the AIDS-causing human immunodeficiency ...

Medical research

Targeting a cell cycle inhibitor promotes beta cell replication

Researchers replicated human pancreatic beta cells—which produce insulin—in a mouse model in which donor cells were transplanted. The newly replicated cells retained features of mature beta cells and showed a physiological ...

Cancer

Tipping the balance between senescence and proliferation

An arrest in cell proliferation, also referred to as cellular senescence, occurs as a natural result of aging and in response to cellular stress. Senescent cells accumulate with age and are associated with many aging phenotypes, ...

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