Max Delbrück Center for Molecular Medicine

The Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) in Berlin, Germany is one of the sixteen research centers of the Helmholtz Association of German Research Centres.


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Cholesterol-lowering drugs may slow down metastases

Cancer patients rarely die from the primary tumor, but rather from the metastases—even after successful tumor surgery. This is because cancer cells sometimes spread to other parts of body early in the disease, when the ...


Restoring heart elasticity in a heart failure model

Patients with heart failure often have shortness of breath and become fatigued quickly. They frequently suffer from water retention, heart palpitations, and dizziness. The condition can be triggered by a combination of elevated ...

Oncology & Cancer

Understanding the tricks of lymphomas

Cellular immunotherapies have so far not been very effective against non-Hodgkin's lymphoma. A team led by Armin Rehm of the MDC has discovered a possible reason. As the they describe in Cell Reports, this cancer induces ...

Oncology & Cancer

The signatures of peritoneal metastases

Surgical removal of the primary tumor is usually not enough. One in two colorectal cancer patients develops distant metastases. In about 30 percent of the cases, they appear in the lining of the abdominal cavity—the peritoneum. ...

Diseases, Conditions, Syndromes

Understanding lung damage in patients with COVID-19

A severe course of COVID-19 disease is not caused by the direct destruction of the lung due to the multiplication of the virus. As researchers from Berlin report in the journal Nature Communications, inflammatory processes ...

Oncology & Cancer

Probing deeper into tumor tissues

Today, as they did 100 years ago, doctors diagnose cancer by taking tissue samples from patients, which they usually fix in formalin for microscopic examination. In the past 20 years, genetic methods have also been established ...


Low levels of a simple sugar: A new biomarker for severe MS?

Multiple sclerosis, or MS for short, manifests itself slightly differently in each person—which is why some call it "the disease of a thousand faces." Arguably the worst manifestation of MS is its chronic progressive form. ...


A milestone in muscular dystrophy therapy

Muscle stem cells enable our muscle to build up and regenerate over a lifetime through exercise. But if certain muscle genes are mutated, the opposite occurs. In patients suffering from muscular dystrophy, the skeletal muscle ...


Too much salt suppresses phagocytes

For many of us, adding salt to a meal is a perfectly normal thing to do. We don't really think about it. But actually, we should. As well as raising our blood pressure, too much salt can severely disrupt the energy balance ...


Fasting acts as diet catalyst in those with metabolic syndrome

One in four Germans suffers from metabolic syndrome. Several of four diseases of affluence occur at the same time in this 'deadly quartet': obesity, high blood pressure, lipid metabolism disorder and diabetes mellitus. Each ...

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