Osaka University

Genetics

Big data provides clues for characterizing immunity in Japanese

Although genes are distributed widely across chromosomes, many genes related to the immune system are clustered together on human chromosome 6 in a segment called the major histocompatibility complex (MHC) region. The density ...

Oncology & Cancer

Addressing expected challenges after resumption of HPV vaccination

In Japan, an HPV vaccination program started in 2010, and the HPV vaccine became a nationally recommended routine immunization for girls aged 12–16 years in April 2013. However, because cases of young girls with widespread ...

Medical research

Resist! TAK1 enables endothelial cells to avoid apoptosis

Cell death is an important aspect of tissue homeostasis, as well as inflammation and disease pathogenesis related to infection, injury, and tumor growth. Tumor necrosis factor-α (TNFα) coordinates cell death in a variety ...

Diseases, Conditions, Syndromes

Lung neuropeptide exacerbates lethal influenza virus infection

Severe influenza virus infection is characterized by a strong inflammatory response and profuse viral replication in lungs. These viruses, such as the notorious avian flu, have a high rate of death and to date there are no ...

Oncology & Cancer

Semaphorin linked to lung cancer treatment resistance

Lung cancer remains a major cause of mortality across the globe, although we are gaining a deeper understanding of the genetic background behind this disease, including the mutations that promote it. Mutation in the gene ...

Surgery

Mapping residual esophageal tumors—a glimpse into the future?

It's one of the first questions asked by many newly-diagnosed cancer patients—"What are my chances of beating this?" Often there is no clear answer, with survival rates differing widely depending on the cancer stage and ...

Medical research

Study differentiates iPS cells into various ocular lineages

The discovery of pluripotent stem cells, which have the ability to differentiate into the huge range of different cell lineages that make up the human body, signaled the start of a new era in biological science and medicine. ...

page 3 from 14